1339075-24-9

Basic information

• Product Name: diethyl (1-([1,1'-biphenyl]-4-yl)-3-(N-(benzyloxy)acetamido)-propyl)phosphonate
• CAS NO: 1339075-24-9
• Molecular Weight: 495.555
• Mol File: 1339075-24-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diethyl (1-([1,1'-biphenyl]-4-yl)-3-(N-(benzyloxy)acetamido)-propyl)phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (1-([1,1'-biphenyl]-4-yl)-3-(N-(benzyloxy)acetamido)-propyl)phosphonate(1339075-24-9)
• EPA Substance Registry System: diethyl (1-([1,1'-biphenyl]-4-yl)-3-(N-(benzyloxy)acetamido)-propyl)phosphonate(1339075-24-9)

Safety Data

• Hazardous Substances Data: 1339075-24-9(Hazardous Substances Data)

Upstream product

• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 113538-22-0 (E)-3-([1,1′-biphenyl]-4-yl)acrylaldehyde 
• 5122-94-1 4-biphenylboronic acid 
• 1339075-16-9 diethyl (1-([1,1'-biphenyl]-4-yl)-3-oxopropyl)phosphonate 

Relevant articles and documents

Synthesis of functionalized cinnamaldehyde derivatives by an oxidative heck reaction and their use as starting materials for preparation of Mycobacterium tuberculosis 1-deoxy-d-xylulose-5-phosphate reductoisomerase inhibitors

Cinnamaldehyde derivatives were synthesized in good to excellent yields in one step by a mild and selective, base-free palladium(II)-catalyzed oxidative Heck reaction starting from acrolein and various arylboronic acids. Prepared α,β-unsaturated aldehydes were used for synthesis of novel α-aryl substituted fosmidomycin analogues, which were evaluated for their inhibition of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate reductoisomerase. IC50 values between 0.8 and 27.3 μM were measured. The best compound showed activity comparable to that of the most potent previously reported α-aryl substituted fosmidomycin-class inhibitor.