13391-79-2Relevant academic research and scientific papers
Development of Transition-Metal-Free Lewis Acid-Initiated Double Arylation of Aldehyde: A Facile Approach Towards the Total Synthesis of Anti-Breast-Cancer Agent
Singh, Sanjay,Mahato, Rina,Sharma, Pragya,Yadav, Naveen,Vodnala, Nagaraju,Kumar Hazra, Chinmoy
supporting information, (2022/02/19)
This work describes a mild and robust double hydroarylation strategy for the synthesis of symmetrical /unsymmetrical diaryl- and triarylmethanes in excellent yields using Lambert salt (0.2–1.0 mol%). Despite the anticipated challenges associated with controlling selective product formation, unsymmetrical diaryl- and triarylmethanes products are obtained unprecedentedly. A highly efficient gram scale reaction has also been reported (TON for symmetrical product=475 and for unsymmetrical product=390). The synthetic utility of the methodology is demonstrated by the preparation of several unexplored diaryl- and triarylmethane-based biologically relevant molecules, such as arundine, vibrindole A, turbomycin B, and certain anti-inflammatory agents. A total synthesis of an anti-breast-cancer agent is also demonstrated. Control experiments, Hammett analysis, HRMS and GC-MS studies reveal the reaction intermediates and reaction mechanism.
Uranyl-catalyzed hydrosilylation ofpara-quinone methides: access to diarylmethane derivatives
Yu, Jipan,Chen, Siyu,Liu, Kang,Yuan, Liyong,Mei, Lei,Chai, Zhifang,Shi, Weiqun
supporting information, p. 1575 - 1579 (2021/03/01)
An efficient and convenient uranyl-catalyzed reductive hydrosilylation reaction ofpara-quinone methides (p-QMs) was developed by employing silane as the reductant. The hydrosilylation procedure using the UO2(NO3)2·6H2
B(C6F5)3 catalysed reduction of: Para -quinone methides and fuchsones to access unsymmetrical diaryl- and triarylmethanes: Elaboration to beclobrate
Mahesh, Sriram,Vijaya Anand, Ramasamy
, p. 8393 - 8401 (2017/10/19)
A mild and efficient method for the synthesis of unsymmetrical diaryl- and triarylmethanes through a B(C6F5)3 catalyzed reduction of para-quinone methides and fuchsones respectively, using the Hantzsch ester as a reducing source has been developed. Detailed mechanistic investigations revealed that the reaction actually proceeds through a Lewis acid-base pair complex derived from B(C6F5)3 and the Hantzsch ester.
