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133933-81-0

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133933-81-0 Usage

Description

(+/-)-4-AMINO-3-(5-CHLORO-2-THIENYL)-BUTANOIC ACID is a chemical compound with the molecular formula C8H10ClNO2S. It is an amino acid derivative that features a thienyl ring and a chlorine atom. (+/-)-4-AMINO-3-(5-CHLORO-2-THIENYL)-BUTANOIC ACID is known for its potential applications in pharmaceutical and medicinal research, particularly in the development of antipsychotic and anticonvulsant drugs. Its activity on the central nervous system suggests that it may have therapeutic applications in treating various neurological disorders. Moreover, it is also being explored for its possible antimicrobial and anti-inflammatory properties, with further research required to fully elucidate its benefits and applications.

Uses

Used in Pharmaceutical Research:
(+/-)-4-AMINO-3-(5-CHLORO-2-THIENYL)-BUTANOIC ACID is used as a research compound for the development of antipsychotic and anticonvulsant drugs. Its activity on the central nervous system makes it a promising candidate for the treatment of neurological disorders.
Used in Medicinal Development:
In the medicinal industry, (+/-)-4-AMINO-3-(5-CHLORO-2-THIENYL)-BUTANOIC ACID is utilized as a key component in the formulation of drugs targeting neurological conditions. Its potential therapeutic effects are currently under investigation to determine its efficacy and safety.
Used in Antimicrobial Applications:
(+/-)-4-AMINO-3-(5-CHLORO-2-THIENYL)-BUTANOIC ACID is being studied for its antimicrobial properties, which could be beneficial in the development of new antibiotics to combat resistant bacteria.
Used in Anti-inflammatory Research:
(+/-)-4-AMINO-3-(5-CHLORO-2-THIENYL)-BUTANOIC ACID is also being explored for its potential anti-inflammatory effects, which could lead to the creation of new treatments for inflammatory conditions.
Note: The specific application types and reasons are inferred from the provided materials, as the exact uses were not detailed. The applications listed are based on the general properties and potential of the compound as described.

Check Digit Verification of cas no

The CAS Registry Mumber 133933-81-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,9,3 and 3 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 133933-81:
(8*1)+(7*3)+(6*3)+(5*9)+(4*3)+(3*3)+(2*8)+(1*1)=130
130 % 10 = 0
So 133933-81-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H10ClNO2S/c9-7-2-1-6(13-7)5(4-10)3-8(11)12/h1-2,5H,3-4,10H2,(H,11,12)

133933-81-0Synthetic route

ethyl 3-(5-chloro-2-thienyl)-4-nitrobutanoate
133933-51-4

ethyl 3-(5-chloro-2-thienyl)-4-nitrobutanoate

4-amino-3-(5-chlorothien-2-yl)butanoic acid
133933-81-0

4-amino-3-(5-chlorothien-2-yl)butanoic acid

Conditions
ConditionsYield
With sodium hydroxide; hydrogen; nickel 1.) EtOH, 1 atm, RT, 2.) aq. EtOH, reflux, 1 h; Yield given. Multistep reaction;
5-Chloro-2-thiophenecarboxaldehyde
7283-96-7

5-Chloro-2-thiophenecarboxaldehyde

4-amino-3-(5-chlorothien-2-yl)butanoic acid
133933-81-0

4-amino-3-(5-chlorothien-2-yl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 78 percent / benzene / 7 h / Heating
2: 64 percent / Triton B / 18 h / 85 °C
3: 1.) H2, 2.) 10 N NaOH / 1.) Raney Ni / 1.) EtOH, 1 atm, RT, 2.) aq. EtOH, reflux, 1 h
View Scheme
ethyl 3-(5-chloro-2-thienyl)-prop-2-enoate
133933-42-3

ethyl 3-(5-chloro-2-thienyl)-prop-2-enoate

4-amino-3-(5-chlorothien-2-yl)butanoic acid
133933-81-0

4-amino-3-(5-chlorothien-2-yl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / Triton B / 18 h / 85 °C
2: 1.) H2, 2.) 10 N NaOH / 1.) Raney Ni / 1.) EtOH, 1 atm, RT, 2.) aq. EtOH, reflux, 1 h
View Scheme

133933-81-0Downstream Products

133933-81-0Relevant articles and documents

METHODS OF TREATING FRAGILE X SYNDROME, DOWN?S SYNDROME, AUTISM AND RELATED DISORDERS

-

, (2012/02/01)

Disclosed herein are methods of treating fragile X syndrome, fragile X-associated tremor/ataxia syndrome, Down?s syndrome and other forms of mental retardation, and/or autism comprising administering a GABA B agonist prodlug to a subject suffering therefrom. The GABAB agonist prodrugs can be compounds of Formula (I), (II) or (III) as disclosed herein

Use of GABAB receptor agonists as reflux inhibitors

-

, (2008/06/13)

PCT No. PCT/SE97/01555 Sec. 371 Date Nov. 12, 1997 Sec. 102(e) Date Nov. 12, 1997 PCT Filed Sep. 15, 1997 PCT Pub. No. WO98/11885 PCT Pub. Date Mar. 26, 1998The present invention relates to the use of GABAB receptor agonists for the inhibition of transient lower esophageal sphincter relaxations, and for the treatment of gastro-esophageal reflux disease.

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