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CAS No.: | 133933-81-0 |
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Name: | (+/-)-4-AMINO-3-(5-CHLORO-2-THIENYL)-BUTANOIC ACID |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C8H10 Cl N O2 S |
Molecular Weight: | 219.692 |
Synonyms: | (+/-)-4-AMINO-3-(5-CHLORO-2-THIENYL)-BUTANOIC ACID;4-amino-3-(5-chloro-2-thienyl)butyric acid |
Density: | 1.41g/cm3 |
Boiling Point: | 360.9°Cat760mmHg |
Flash Point: | 172.1°C |
PSA: | 91.56000 |
LogP: | 2.61880 |
ethyl 3-(5-chloro-2-thienyl)-4-nitrobutanoate
4-amino-3-(5-chlorothien-2-yl)butanoic acid
Conditions | Yield |
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With sodium hydroxide; hydrogen; nickel 1.) EtOH, 1 atm, RT, 2.) aq. EtOH, reflux, 1 h; Yield given. Multistep reaction; |
5-Chloro-2-thiophenecarboxaldehyde
4-amino-3-(5-chlorothien-2-yl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 78 percent / benzene / 7 h / Heating 2: 64 percent / Triton B / 18 h / 85 °C 3: 1.) H2, 2.) 10 N NaOH / 1.) Raney Ni / 1.) EtOH, 1 atm, RT, 2.) aq. EtOH, reflux, 1 h View Scheme |
ethyl 3-(5-chloro-2-thienyl)-prop-2-enoate
4-amino-3-(5-chlorothien-2-yl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 64 percent / Triton B / 18 h / 85 °C 2: 1.) H2, 2.) 10 N NaOH / 1.) Raney Ni / 1.) EtOH, 1 atm, RT, 2.) aq. EtOH, reflux, 1 h View Scheme |