133951-08-3

Basic information

• Product Name: 9-Deoxo-FK 506
• Synonyms: 9-Deoxo-FK 506
• CAS NO: 133951-08-3
• Molecular Weight: 790.048
• Mol File: 133951-08-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 9-Deoxo-FK 506(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Deoxo-FK 506(133951-08-3)
• EPA Substance Registry System: 9-Deoxo-FK 506(133951-08-3)

Safety Data

• Hazardous Substances Data: 133951-08-3(Hazardous Substances Data)

Upstream product

• 181229-32-3 9-deoxo-31-O-demethyl-FK₅₀₆ 
• 133941-60-3 24,33-Bis-(t.butyl-dimethylsilyl)-9(R)-dihydro-FK 506-9,10-thiocarbonate 
• 133941-60-3 24,33-Bis-(t.butyl-dimethylsilyl)-9(S)-dihydro-FK 506-9,10-thiocarbonate 
• 133941-67-0 (E)-24,33-Bis-(t.butyl-dimethylsilyl)-Δ⁹-FK 506 
• 144895-59-0 (Z)-24,33-Bis-(t.butyl-dimethylsilyl)-Δ⁹-FR 900520 
• 133941-67-0 24,33-Bis-(t.butyl-dimethylsilyl)-Δ⁹-11-epi-FK 506 
• 133941-67-0 24,33-Bis-(t.butyl-dimethylsilyl)-Δ⁹-FK 506 
• 144895-55-6 24,33-Bis-(t.butyl-dimethylsilyl)-Δ¹⁰-FK 506 
• 104987-11-3 Tacrolimus 

Downstream Products

• 1186414-49-2 9-hydroxyFK₅₀₆ 
• 104987-11-3 Tacrolimus 

Relevant articles and documents

Characterization of FK506 biosynthetic intermediates involved in post-PKS elaboration

The post-PKS modification steps of FK506 biosynthesis include C9-oxidation and 31-O-methylation, but the sequence of these reactions and the exact route have remained unclear. This study details the post-PKS modification pathways in FK506 biosynthesis thr

Synthesis of Derivatives of FK 506 and FR 900520: Modifications at the Binding Domain

The synthesis of 9-deoxo-FK 506 (13a), 9-deoxo-FR 900520 (13b), 9-deoxo-10(R)-deoxy-FR900520 (14) and its 10(S) isomer 15 is described.Radical deoxygenation/elimination of the 9-dihydro-9,10-thiocarbonates 5a,5b,6a and 6b gave the 9,10 unsaturated compoun