133957-57-0

Basic information

• Product Name: 3-hydroxy-1-phenyl-1-decanone
• Synonyms: 3-hydroxy-1-phenyl-1-decanone
• CAS NO: 133957-57-0
• Molecular Weight: 248.365
• Mol File: 133957-57-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-1-phenyl-1-decanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-1-phenyl-1-decanone(133957-57-0)
• EPA Substance Registry System: 3-hydroxy-1-phenyl-1-decanone(133957-57-0)

Safety Data

• Hazardous Substances Data: 133957-57-0(Hazardous Substances Data)

Upstream product

• 13735-81-4 1-styrenyloxytrimethylsilane 
• 124-13-0 Octanal 
• 98-86-2 acetophenone 
• 70-11-1 α-bromoacetophenone 
• 4636-16-2 iodoacetophenone 

Relevant articles and documents

Enantioselective Conjugate Azidation of α,β-Unsaturated Ketones under Bifunctional Organocatalysis by Direct Activation of TMSN3

An enantioselective organocatalytic conjugate azidation of α,β-unsaturated ketones is presented. A bifunctional organocatalyst activates TMSN3, triggering the nucleophilic addition of the azido group to enones in absence of external promoters and avoiding the direct use or the pre-formation of highly toxic and explosive hydrazoic acid. This protocol proceeds with excellent enantiocontrol under mild conditions. DFT calculations and mechanistic trials have been performed in order to demonstrate the direct activation performed by the bifunctional organocatalyst. (Figure presented.).

FeCl3·6H2O-catalyzed mukaiyama-aldol type reactions of enolizable aldehydes and acetals

Mukaiyama-aldol type reactions of acetals derived from enolizable aldehydes with FeCl3·6H2O, an eco-friendly, low-cost, and stable catalyst, lead to β-methoxycarbonyl compounds with nearly quantitative yields. The methodology is extended to the parent aldehydes as starting materials, leading to the corresponding aldols with lower yields, but efficiently. Different alkyl and aryl substituted acetals and aldehydes have been tested in the reaction with linear and cyclic silyl enol ethers. Reactions are carried out in an open air atmosphere, and additives are not required. Acetals can be considered activating groups of the carbonyl moiety rather than a protecting group in this type of FeCl3·6H2O-catalyzed condensation.

Tin-mediated organic reactions: A practical method for the synthesis of β-hydroxynitriles and β-hydroxyketones

In the presence of chlorotrimethylsilane, the tin mediated addition of bromoacetonitrile or α-bromacetophenone to aldehydes in THF gives β- hydroxynitriles or β-hydroxyketones in moderate to good yields.