133967-02-9Relevant academic research and scientific papers
Nucleosides. 3. Reactions of AICA-Riboside with Isothiocyanates. A Convenient Synthesis of Isoguanosine and Xanthosine Derivatives
Chern, Ji-Wang,Lin, Gwo-Sen,Chen, Chien-Shu,Townsend, Leroy B.
, p. 4213 - 4218 (2007/10/02)
Cyclodesulfurative annulations of 5--1-(β-D-ribofuranosyl)imidazole-4-carboxamides (3a-h) with N,N-dicyclohexylcarbodiimide are described.Isoguanosine (4) and several 1-substituted isoguanosines 6a-f,h are readily prepared by a ring closure of the appropriate resulting 5-(3-substituted-1-ureido)-1-(β-D-ribofuranosyl)imidazole-4-carbonitriles 5a-h.Treatment of the appropriate 1-substituted isoguanosines under basic conditions has furnished the corresponding 1-substituted xanthosine 12.
