133970-01-1Relevant articles and documents
Naphtho and benzo analogues of the κ opioid agonist trans-(±)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] benzeneacetamide
Freeman,Michalson,D'Andrea,Baczynskyj,VonVoigtlander,Lahti,Smith,Lawson,Scahill,Mizsak,Szmuszkovicz
, p. 1891 - 1896 (1991)
Further elaboration on the structure-activity relationships in our U-50,488 series has revealed that benzologation of this cyclohexane-1,2-diamine derivative provides compounds which either maintain the interaction with the κ receptor (e.g. compounds 3a a