133992-53-7

Upstream product

• 70978-37-9 1-(azidomethyl)-4-methoxybenzene 
• 107-91-5 cyanoacetic acid amide 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1343405-62-8 C₁₅H₁₅N₅O₄ 
• 1343405-63-9 C₁₃H₁₂N₆O₃*H₃N 
• 1343405-64-0 C₁₃H₉ClN₆O 
• 1343405-65-1 C₁₅H₁₅N₇O 
• 1343405-61-7 C₁₅H₁₇N₅O₅ 
• 1433363-06-4 1-(4-methoxybenzyl)-5-pivalamido-1H-1,2,3-triazole-4-carboxamide 
• 1433363-08-6 N-(4-cyano-1-(4-methoxybenzyl)-1H-1,2,3-triazol-5-yl)pivalamide 
• 1433362-88-9 5-tert-butyl-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(4H)-one 
• 1433363-10-0 5-tert-butyl-7-chloro-3-(4-methoxy benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine 
• 1433359-02-4 4-(5-tert-butyl-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine 
• 1190400-10-2 5,7-dichloro-3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine 
• 1438466-67-1 (S)-1-[5-Chloro-3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-pyrrolidin-3-ol 
• 1190400-09-9 3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-diol 
• 1438466-68-2 (S)-1-[3-(4-methoxy-benzyl)-5-(2,2,2-trifluoro-ethoxy)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-pyrrolidin-3-ol 

Relevant academic research and scientific papers

GPR35 MODULATORS

Described herein are GPR35 modulators and methods of using these compounds in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

NOVEL TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES

The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Anticancer activity of newly synthesized triazolopyrimidine derivatives and their nucleoside analogs

New substituted triazolopyrimidne derivatives were synthesized starting from 1,2,3-triazolo-4-carboxamide derivative. The N- and S-glycoside derivatives of the synthesized triazolopyrimidine ring system as well as their acyclic sugar analogs were also syn

NOVEL [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES

The invention relates to a compound of formula (I) wherein A, R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

[1, 2, 3] TRIAZOLO [4, 5 -D] PYRIMIDINE DERIVATIVES AS AGONISTS OF THE CANNABINOID RECEPTOR 2

The invention relates to a compound of formula (I), wherein A, R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament as agonists of the cannabinoid receptor 2.

[1, 2, 3]TRIAZOLO [4, 5 -D] PYRIMIDINE DERIVATIVES AS AGONISTS OF THE CANNABINOID RECEPTOR 2 AGONISTS

The invention relates to a compound of formula (I) wherein A and R to R 3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

NOVEL [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES

The invention relates to a compound of formula (I) wherein A and R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Synthesis of novel 2-cyano-7-deaza-8-azapurine- and 2-cyano-8-azapurine- derived nucleosides

A novel systematic approach to the synthesis of 2-cyano-7-deaza-8-azapurine derived nucleosides is described. It is shown how this chemistry was developed with the labile 2-substituted nitrile position in mind, and also how the same approach is applicable to 2-cyano-8-azapurine derived nucleosides.

An Improved Procedure for the Preparation of 1-Benzyl-1H-1,2,3-triazoles from Benzyl Azides.

A procedure for the preparation of substituted 1-benzyl-1H-1,2,3-triazoles from benzyl azides under very mild conditions is described.The method provides improved yields and extends the scope of the Dimroth Reaction to other types of active methylene compound to those previously used.Benzyl azides react with active methylene compounds in dimethyl sulphoxide catalysed by potassium carbonate at 35-40 deg C to give 1H-1,2,3-triazoles usually in good yield.Acetonitrile derivatives gave 5-amino-1H-1,2,3-triazoles whereas diethyl malonate gave 5-hydroxy-1H-1,2,3-triazoles. 1H-1,2,3-Triazole-4-carboxylate esters and 1H-1,2,3-triazole-4-ketones were obtained from ethyl acetoacetate and β-diketones respectively.Benzyl methyl ketone reacted to give 5-methyl-4-phenyl-1H-1,2,3-triazole, but acetone and acetophenone failed to react.Other active methylene compounds which did not react under these reaction conditions included ethyl cyanoacetate, ethyl fluoroacetate and ethyl nitroacetate.