133992-62-8

Upstream product

• 622-79-7 benzyl azide 
• 93-91-4 1-phenylbutan-1,3-dione 
• 1817-57-8 4-phenyl-3-butyne-2-one 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 591-50-4 iodobenzene 
• 1423-60-5 methyl ethynyl ketone 
• 108-86-1 bromobenzene 

Relevant academic research and scientific papers

Regioselective synthesis of functionalized 1,2,3-triazoles via oxidative [3+2]-cycloaddition using Zn(OAc)2 - tBuOOH or ZnO nanoparticle as catalyst system in aqueous medium

The regioselective synthesis of functionalized pyrazole?1,2,3-triazoles is reported via oxidative [3 + 2]-cycloaddition reactions of azides with β-nitrostyrenes and chalcone derivatives using Zn(OAc)2 - tBuOOH or ZnO nanoparticles as

Organocatalytic 1,3-dipolar cycloaddition reaction of α,β-unsaturated ketones with azides through iminium catalysis

1,3-Dipolar cycloaddition reaction of α,β-unsaturated ketones with azides through iminium catalysis has been developed. This method could furnish 1,4,5-trisubstituted 1,2,3-triazoles in good yields and high levels of regioselectivity.

Another Example of Organo-Click Reactions: TEMPO-Promoted Oxidative Azide–Olefin Cycloaddition for the Synthesis of 1,2,3-Triazoles in Water

The water-mediated, metal-free, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) promoted oxidative [3+2] cycloaddition of organic azides with electron-deficient terminal and internal olefins was explored. A library of 1,4-disubstituted and 1,4,5-trisubstitut

Cu/Pd-catalyzed, three-component click reaction of azide, alkyne, and aryl halide: One-pot strategy toward trisubstituted triazoles

A Cu/Pd-catalyzed, three-component click reaction of azide, alkyne, and aryl halide has been developed. By using this Cu/Pd transmetalation relay catalysis, a variety of 1,4,5-trisubstituted 1,2,3-triazoles were quickly assembled in one step in high yield

Synthesis of functionalized 1,2,3-triazoles using Bi2WO6 nanoparticles as efficient and reusable heterogeneous catalyst in aqueous medium

Synthesis of functionalized triazoles is reported via Bi2WO6 nanoparticle (10 mol%) mediated 1,3-dipolar cycloaddition reactions of β-nitrostyrenes, phenylacetylene and chalcones with azides (80 °C, 2-6 h) in water. The regioselectiv

Regioselective synthesis of triazoles via base-promoted oxidative cycloaddition of chalcones with azides in aqueous solution

A base-promoted oxidative cycloaddition of chalcones with azides in aqueous solution has been developed under transition-metal-free conditions, which provides a green method for the regioselective synthesis of trisubstituted triazoles in good yields.

Copper(I)-catalyzed aerobic oxidative azide-alkene cyclo-addition: An efficient synthesis of substituted 1,2,3-triazoles

A novel, copper(I)-promoted azide-alkene aerobic oxidative cycloaddition protocol was devel-oped for the regioselective synthesis of 1,4-disubsti-tuted/ 1,4,5-trisubstituted 1,2,3-triazoles by using azides and electron-deficient olefins under an oxygen atmosphere.

A study of the scope and regioselectivity of the ruthenium-catalyzed [3 + 2]-cycloaddition of azides with internal alkynes

[3 + 2]-Cycloadditions of alkyl azides with various unsymmetrical internal alkynes in the presence of Cp*RuCl(PPh3)2 as catalyst in refluxing benzene have been examined, leading to 1,4,5-trisubstituted-1,2,3-triazoles. Whereas alkyl

An Improved Procedure for the Preparation of 1-Benzyl-1H-1,2,3-triazoles from Benzyl Azides.

A procedure for the preparation of substituted 1-benzyl-1H-1,2,3-triazoles from benzyl azides under very mild conditions is described.The method provides improved yields and extends the scope of the Dimroth Reaction to other types of active methylene compound to those previously used.Benzyl azides react with active methylene compounds in dimethyl sulphoxide catalysed by potassium carbonate at 35-40 deg C to give 1H-1,2,3-triazoles usually in good yield.Acetonitrile derivatives gave 5-amino-1H-1,2,3-triazoles whereas diethyl malonate gave 5-hydroxy-1H-1,2,3-triazoles. 1H-1,2,3-Triazole-4-carboxylate esters and 1H-1,2,3-triazole-4-ketones were obtained from ethyl acetoacetate and β-diketones respectively.Benzyl methyl ketone reacted to give 5-methyl-4-phenyl-1H-1,2,3-triazole, but acetone and acetophenone failed to react.Other active methylene compounds which did not react under these reaction conditions included ethyl cyanoacetate, ethyl fluoroacetate and ethyl nitroacetate.