133992-79-7Relevant articles and documents
Application of 4-alkoxy-1,1,1-trifluoro[chloro]alk-3-en-2-ones as selective protecting groups of amino acids
Zanatta, Nilo,Squizani, Adriana M. C.,Fantinel, Leonardo,Nachtigall, Fabiane M.,Bonacorso, Helio G.,Martins, Marcos A. P.
, p. 2409 - 2415 (2007/10/03)
A convenient selective protection of the α-amino carboxyl group of amino acids bearing reactive side chain groups such as arginine, asparagine, glutamine, cysteine, histidine, serine and lysine, using 4-alkoxy-1,1,1-trifluoro[chloro]alk-3-en-2-ones is reported. The reactions were performed without esterification of the carboxyl group and N-deprotection was carried out using a six molar solution of hydrochloric acid.