133992-80-0Relevant articles and documents
Synthesis of trifluoromethyl and trifluoroacetyl substituted dihydropyrrolizines and tetrahydroindolizines
Gerus, Igor I.,Klipkov, Anton A.,Rusanova, Julia A.,Sorochinsky, Alexander E.,Tarasenko, Karen V.
, (2020)
The trifluoroacetic anhydride promoted cyclization of enaminones derived from proline or pipecolic acid and β-ethoxyvinyl trifluoromethyl ketone was reinvestigated. An operationally simple procedure for the selective synthesis of bicyclic trifluoromethylated pyrroles and bicyclic pyrroles bearing trifluoromethyl and trifluoroacetyl groups on the pyrrole ring was developed. The mechanism of cyclization explaining the formation of bicyclic trifluoromethylpyrroles was discussed and previously described structures of the cyclization products were corrected.
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one as a new protecting reagent in peptide synthesis
Gorbunova,Gerus,Galushko,Kukhar
, p. 207 - 209 (2007/10/02)
The 4,4,4-trifluoro-3-oxo-1-butenyl group is proposed as a suitable protecting group for the protection of the N-H terminal of amino acids in peptide synthesis. Amino acids react with 4-ethoxy-1,1,1-trifluoro-3-buten-2-one to give the N-protected amino acids, the protecting group can be removed by acidic hydrolysis. The formation of peptide bonds using on N-4,4,4-trifluoro-3-oxo-1-butenyl protected amino acids occurs without racemization.
