134-37-2

Basic information

• Product Name: Amphenidone
• Synonyms: Amphenidone;2(1H)-Pyridinone, 1-(3-aminophenyl)-;1-(META-AMINOPHENYL)-2-PRYIDONE;1-(3-Aminophenyl)-1,2-dihydropyridine-2-one;1-(3-Aminophenyl)-2(1H)-pyridinone;1-(m-Aminophenyl)-2(1H)-pyridone;Dornwal;Dornwall
• CAS NO: 134-37-2
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.213
• Mol File: 134-37-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 182.5-184.5°
• Boiling Point: 320.7°C (rough estimate)
• Flash Point: 210.7°C
• Appearance: /
• Density: 1.1458 (rough estimate)
• Vapor Pressure: 2.02E-07mmHg at 25°C
• Refractive Index: 1.5300 (estimate)
• CAS DataBase Reference: Amphenidone(CAS DataBase Reference)
• NIST Chemistry Reference: Amphenidone(134-37-2)
• EPA Substance Registry System: Amphenidone(134-37-2)

Safety Data

• Hazardous Substances Data: 134-37-2(Hazardous Substances Data)

Usage

Safety Profile

Moderately toxic by ingestion andintravenous routes. When heated to decomposition itemits toxic fumes of NOx.

InChI:InChI=1/C11H10N2O/c12-9-4-3-5-10(8-9)13-7-2-1-6-11(13)14/h1-8H,12H2

Upstream product

• 142-08-5 2-Pyridone 
• 591-19-5 m-Bromoaniline 
• 626-01-7 3-Iodoaniline 

Relevant articles and documents

Cu-catalyzed N- and O-arylation of 2-,3-, and 4-hydroxypyridines and hydroxyquinolines

With use of Cu-based catalysts, 2- and 4-hydroxypyridines were N-arylated in modest to excellent yields. In the case of 2-hydroxypyridine, the use of 4,7-dimethoxy-1,10-phenanthroline, 3, expanded the scope of previous literature reports to include the use of N-containing heteroaryl halides, and 2-substituted aryl halides. In addition, by using a copper catalyst based on 2,2,6,6-tetramethylheptane-3,5-dione, 4, the first N-arylations of 4-hydroxypyridines and O-arylations of 3-hydroxypyridines with aryl bromides and iodides have been accomplished.