134029-48-4

Upstream product

• 165258-79-7 N-(t-butyloxycarbonyl)varacin 
• 149625-16-1 [2-(4,5-Dimethoxy-2,3-bis-propylsulfanyl-phenyl)-ethyl]-carbamic acid 2-trimethylsilanyl-ethyl ester 
• 149625-14-9 1,2-Dimethoxy-5-((E)-2-nitro-vinyl)-3,4-bis-propylsulfanyl-benzene 
• 149625-11-6 4,5-Dimethoxy-2,3-bis-propylsulfanyl-benzaldehyde 
• 149625-15-0 2-(4,5-Dimethoxy-2,3-bis-propylsulfanyl-phenyl)-ethylamine 
• 121-33-5 vanillin 
• 6948-30-7 5-bromoveratralaldehyde 
• 70625-29-5 2,3-dibromo-4,5-dimethoxybenzaldehyde 
• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 
• 149625-17-2 6,7-Dimethoxy-9-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>benzopentathiepin 

Relevant academic research and scientific papers

Isodiplamine, cystodytin K and lissoclinidine: Novel bioactive alkaloids from the New Zealand ascidian Lissoclinum notti

A study of the bioactive crude extract of the New Zealand ascidian Lissoclinum notti led to the isolation of the new pyridoacridine alkaloids isodiplamine (4), cystodytin K (5) and lissoclinidine (6), as well as the known pyridoacridine alkaloids diplamine (7) and cystodytin J (8) and the benzopentathiepin varacin (3) and related trithiane varacin A. The new alkaloids were characterised using standard spectroscopic techniques, including 2D 1H-15N NMR experiments. Pyridoacridine alkaloids 4-8 were assayed for a range of biological activities including antitumour and antibiotic properties.

Synthesis of Varacin, a Cytotoxic Naturally Occurring Benzopentathiepin Isolated from a Marine Ascidian

The total synthesis of varacin (1), a cytotoxic metabolite isolated from a marine ascidian, has been accomplished in 11 steps from vanillin, providing unambiguous confirmation of the unique dopamine-related benzopentathiepin structure.