134031-41-7

Upstream product

• 50-00-0 formaldehyd 
• 134031-40-6 (+/-)-(1R*,5S*,7S*)-4-(E)-ethylidene-7-hydroxy-7-<1-(2-(trimethylacetamido)phenyl)ethenyl>-2-azabicyclo<3.2.1>octane 
• 930-30-3 cyclopent-2-enone 
• 134031-33-7 (E)-3-<1-(hydroxymethyl)-1-propenyl>cyclopentanone 
• 134031-34-8 (E)-3-<1-(((triisopropylsilyl)oxy)methyl)-1-propenyl>cyclopentanone 
• 134031-36-0 (E)-4-<1-(((triisopropylsilyl)oxy)methyl)-1-propenyl>-1-<(N-methoxy-N-methylamino)carbonyl>cyclopentene 
• 134031-42-8 (+/-)-(1R*,2R*,4R*)-4-<1-(chloromethyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)phenyl)ethenyl>-6-oxabicyclo<3.1.0>hexane 
• 147806-34-6 N-(2-{1-[(1R,3R,5R)-3-((E)-1-Hydroxymethyl-propenyl)-6-oxa-bicyclo[3.1.0]hex-1-yl]-vinyl}-phenyl)-2,2-dimethyl-propionamide 
• 134031-37-1 (E)-4-<1-(((triisopropylsilyl)oxy)methyl)-1-propenyl>-1-<1-(2-trimethylacetamido)benzoyl>cyclopentene 
• 134031-39-3 (+/-)-(1R*,2R*,4R*)-4-<(1-((triisopropylsilyl)oxy)methyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)phenyl)ethenyl>-6-oxabicyclo<3.1.0>hexane 
• 147806-04-0 N-(2-{1-[(1R,5S,7S)-4-Eth-(E)-ylidene-7-hydroxy-2-(2,2,2-trifluoro-acetyl)-2-aza-bicyclo[3.2.1]oct-7-yl]-vinyl}-phenyl)-2,2-dimethyl-propionamide 
• 134031-38-2 (+/-)-(1R*,2S*,4S*)-4-<(1-((triisopropylsilyl)oxy)methyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)benzoyl)>-6-oxabicyclo<3.1.0>hexane 
• 65854-92-4 N-(2-bromophenyl)-2,2-dimethylpropanamide 
• 134031-35-9 (E)-1-(trifluoromethanesulfonyl)-4-<1-(((triisopropylsilyl)oxy)methyl)-1-propenyl>cyclopentene 

Relevant academic research and scientific papers

The aza-Cope-Mannich approach to Strychnos alkaloids. Short stereocontrolled total syntheses of (±)-dehydrotubifoline and (±)-akuammicine

A direct approach for the total synthesis of Strychnos alkaloids has been developed. The key strategic element is the aza-Cope-Mannich rearrangement (Scheme II) of formaldiminium ions derived from azabicyclo[3.2.1]octanols 5 (Scheme I). This reorganizatio