134038-47-4Relevant academic research and scientific papers
From N-Nitroacetylproline to Leucylproline
Manjunatha, Sulur G.,Rajappa, Srinivasachari
, p. 372 - 373 (2007/10/02)
The potential of the nitroacetyl group in peptide synthesis has been demonstrated by converting N-nitroacetylproline ethyl ester into cyclo(L-Leu-L-Pro).
Nitroacetyl Group as a Peptide Synthon: Synthesis of Dipeptides with an α,α-Bisallylglycine Residue at the N-Terminus
Manjunatha, Sulur G.,Chittari, Pabba,Rajappa, Srinivasachari
, p. 1071 - 1080 (2007/10/02)
N-Nitroacetyl derivatives of L-proline, L-valine, and L-phenylalanine esters were prepared in two steps under mild conditions (Scheme 2).Regiospecific mono- and bis-allylation of these nitroacetyl derivatives were accomplished in presence of a Pd(0) catalyst.The bis-allyl derivatives 7-9 were obtained in 40-75 percent yield.The tertiary NO2 group in these compounds could be transformed into an acetylamino group by Zn/AcOH/Ac2O.The final products 11-13 are dipeptides in which the N-terminal glycine residue bears two α-allyl substituents.
