134038-66-7Relevant academic research and scientific papers
Synthesis of Potential Agonists and Antagonists for Central Glutamate Receptors by a Novel 'Ring Switching' Process
Bowler, Andrew N.,Doyle, Paul M.,Young, Douglas W.
, p. 314 - 316 (1991)
Heterocyclic derivatives 6 of (S)-glutamic acid, which are structurally related to key central nervous system (CNS) glutamate receptor agonists,are prepared from the aldehyde 9 using a novel reaction in which the pyroglutamate ring is cleaved in concert with formation of the new heterocyclic ring.
Synthesis of agonists and antagonists for central glutamate receptors by a novel 'ring switching' strategy
Bowler, Andrew N.,Dinsmore, Andrew,Doyle, Paul M.,Young, Douglas W.
, p. 1297 - 1306 (2007/10/03)
A novel and versatile ring switching strategy has been developed for the synthesis of compounds with structural features consistent with activity at glutamate receptors. A variety of homochiral L-alanine derivatives substituted at the β-carbon atom with planar five and six-membered heteroaromatic rings have been prepared in a one- or two-pot reaction using this strategy and some of the products have been shown to have biological activity at central glutamate receptors.
