134038-68-9Relevant academic research and scientific papers
Synthesis of agonists and antagonists for central glutamate receptors by a novel 'ring switching' strategy
Bowler, Andrew N.,Dinsmore, Andrew,Doyle, Paul M.,Young, Douglas W.
, p. 1297 - 1306 (2007/10/03)
A novel and versatile ring switching strategy has been developed for the synthesis of compounds with structural features consistent with activity at glutamate receptors. A variety of homochiral L-alanine derivatives substituted at the β-carbon atom with planar five and six-membered heteroaromatic rings have been prepared in a one- or two-pot reaction using this strategy and some of the products have been shown to have biological activity at central glutamate receptors.
Synthesis of Potential Agonists and Antagonists for Central Glutamate Receptors by a Novel 'Ring Switching' Process
Bowler, Andrew N.,Doyle, Paul M.,Young, Douglas W.
, p. 314 - 316 (2007/10/02)
Heterocyclic derivatives 6 of (S)-glutamic acid, which are structurally related to key central nervous system (CNS) glutamate receptor agonists,are prepared from the aldehyde 9 using a novel reaction in which the pyroglutamate ring is cleaved in concert with formation of the new heterocyclic ring.
