134039-54-6

Basic information

• Product Name: 1,2,3,4-TETRAHYDRO-5-IODO-1,3,6-TRIMETHYL-2,4-DIOXOPYRIMIDINE
• Synonyms: 1,2,3,4-TETRAHYDRO-5-IODO-1,3,6-TRIMETHYL-2,4-DIOXOPYRIMIDINE;5-IODO-1,3,6-TRIMETHYLURACIL;1,3,6-Trimethyl-5-iodouracil;5-IODO-1,3,6-TRIMETHYLURACIL(WXG02327)
• CAS NO: 134039-54-6
• Molecular Formula: C₇H₉IN₂O₂
• Molecular Weight: 280.06
• Mol File: 134039-54-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 152-153 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 273.01 °C at 760 mmHg
• Flash Point: 118.912 °C
• Appearance: /
• Density: 1.91 g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.64
• PKA: -3.51±0.60(Predicted)
• CAS DataBase Reference: 1,2,3,4-TETRAHYDRO-5-IODO-1,3,6-TRIMETHYL-2,4-DIOXOPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-TETRAHYDRO-5-IODO-1,3,6-TRIMETHYL-2,4-DIOXOPYRIMIDINE(134039-54-6)
• EPA Substance Registry System: 1,2,3,4-TETRAHYDRO-5-IODO-1,3,6-TRIMETHYL-2,4-DIOXOPYRIMIDINE(134039-54-6)

Safety Data

• Hazardous Substances Data: 134039-54-6(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic organic compound

Structure

Contains a pyrimidine ring and an iodine atom

Potential applications

a. Pharmaceuticals
b. Agrochemicals

Biological activity

As a pyrimidine derivative, it may have biological activity

Synthesis

Can be used as a building block for the synthesis of more complex organic molecules

Iodine substituent

Could potentially impart specific properties useful in certain applications

Relevance

Potential relevance in various chemical and biological contexts

InChI:InChI=1/C7H9IN2O2/c1-4-5(8)6(11)10(3)7(12)9(4)2/h1-3H3

Upstream product

• 1461-67-2 5-iodine-6-methyl-1H-pyrimidine-2,4-dione 
• 74-88-4 methyl iodide 
• 13509-52-9 1,3,6-trimethyluracil 

Downstream Products

• 343850-60-2 (S)-2-tert-butoxycarbonylamino-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid methyl ester 
• 107077-52-1 6-hydroxymethyl-1,3-dimethyluracil 
• 13509-52-9 1,3,6-trimethyluracil 
• 15018-59-4 5-bromo-1,3,6-trimethylpyrimidine-2,4(1 H,3H)-dione 
• 343850-61-3 (S)-2-amino-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid methyl ester hydrochloride 
• 1428442-20-9 C₁₈H₂₃N₃O₄ 
• 1428442-18-5 C₂₃H₃₁N₃O₆ 
• 343851-08-1 N-(benzyloxycarbonyl)-4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-3-methyl-L-phenylalanine methyl ester 

Relevant articles and documents

SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

Provided is a sulfonamide derivative represented by the following general formula (1) and having an α4 integrin inhibitory effect with high selectivity with a low effect on α4β1 and a high effect on α4β7, or a pharmaceutically acceptable salt thereof (in the general formula (1), A, B, D, E, R41, and a to h are as described in the description).

4-Pyrimidinyl-n-acyl-l phenylalanines

Compounds of Formula I are disclosed, having activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.