1461-67-2

Basic information

• Product Name: 5-IODO-6-METHYLURACIL
• Synonyms: 5-IODO-6-METHYLURACIL;5-iodo-6-methyl-1H-pyrimidine-2,4-dione;5-iodo-6-MethylpyriMidine-2,4(1H,3H)-dione;5-iodo-6-MethylpyriMidine-2,4-diol
• CAS NO: 1461-67-2
• Molecular Formula: C₅H₅IN₂O₂
• Molecular Weight: 252.01
• Mol File: 1461-67-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 280 °C (dec.)(lit.)
• Appearance: /
• Density: 2.17 g/cm³
• Refractive Index: 1.666
• Storage Temp.: -20°C
• PKA: 8.07±0.10(Predicted)
• CAS DataBase Reference: 5-IODO-6-METHYLURACIL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-IODO-6-METHYLURACIL(1461-67-2)
• EPA Substance Registry System: 5-IODO-6-METHYLURACIL(1461-67-2)

Safety Data

• Hazard Codes: Xn
• Statements: 40-42/43
• Safety Statements: 22-26-36
• WGK Germany: 3
• Hazardous Substances Data: 1461-67-2(Hazardous Substances Data)

Usage

General Description

5-Iodo-6-methyluracil is a chemical compound with the molecular formula C5H5IN2O2. This substance belongs to the group of chemicals known as halopyrimidines, specifically a class of organic compounds known as 5-halouracils. 5-Iodo-6-methyluracil is less known and hasn't been widely studied or applied in industry, pharmaceuticals, or laboratory settings, due to its highly specialized nature. Safety, toxicity, and physiological effects of this chemical compound remain largely unknown. However, as a chemical analogue of uracil, a component of RNA, it could possibly have applications in biochemical research or in the development of pharmaceuticals. Further research and investigation is aided by its solid state, allowing it to be easily stored and handled in a laboratory setting.

InChI:InChI=1/C5H5IN2O2/c1-2-3(6)4(9)8-5(10)7-2/h1H3,(H2,7,8,9,10)

Upstream product

• 626-48-2 6-Methyluracil 
• 626-48-2 2,4-dihydroxy-6-methylpyrimidine 

Downstream Products

• 134039-54-6 1,2,3,4-Tetrahydro-5-iodo-1,3,6-trimethyl-2,4-dioxopyrimidine 
• 1146966-39-3 C₂₃H₂₅IN₂O₅ 
• 1174267-63-0 1,3-dibenzyl-5-iodo-6-phenethyluracil 
• 15018-56-1 5-bromo-6-methyluracil 
• 62459-19-2 5,5-dibromo-6-hydroxy-6-methyl-5,6-dihydrouracil 

Relevant articles and documents

Oxidative halogenation of 6-methyluracil

An efficient method has been developed for the preparation of halo derivatives of 6-methyluracil by employing oxidative halogenation. Elemental halogens and potassium halides were used as the halogenating agents, while NaNO3 and H2O2 were used as the oxidizing agents. Iodination of 6-methyl-uracil leads to 5-iodo-6-methyluracil as the single reaction product, while bromination or chlorination lead to 5-halo-6-methyluracil, 5,5-dihalo-6-hydroxy-6-methyl-5,6-dihydrouracil, or their mixture depending on the acidity of the medium and the ratio of the substrate and reagents. Bromination of 5-chloro-6-methyluracil leads to 5-bromo-5-chloro-6-hydroxy-6-methyl-5,6-dihydrouracil, while chlorination of 6-methyl-, 5-bromo-6-methyl-, and 5-chloro-6-methyluracils using gaseous chlorine yields 5,5-dichloro-6-hydroxy-6-methyl-5,6-dihydrouracil.

SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

Provided is a sulfonamide derivative represented by the following general formula (1) and having an α4 integrin inhibitory effect with high selectivity with a low effect on α4β1 and a high effect on α4β7, or a pharmaceutically acceptable salt thereof (in the general formula (1), A, B, D, E, R41, and a to h are as described in the description).

Facile alternative synthesis of 1-alkyl-5-alkylamino-6-phenethyluracils

A short alternative synthesis of 1-alkyl-5-alkylamino-6-phenethyluracil is described in 47% overall yield of 1a via five steps starting from commercially available 6-methyluracil.