1340484-08-3

Basic information

• Product Name: (4,4-diphenylbut-3-en-1-yl)-((1H-tetrazol-5-yl)methyl)amine hydrochloride
• Synonyms: (4,4-diphenylbut-3-en-1-yl)-((1H-tetrazol-5-yl)methyl)amine hydrochloride
• CAS NO: 1340484-08-3
• Molecular Weight: 341.843
• Mol File: 1340484-08-3.mol

Chemical Properties

• CAS DataBase Reference: (4,4-diphenylbut-3-en-1-yl)-((1H-tetrazol-5-yl)methyl)amine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (4,4-diphenylbut-3-en-1-yl)-((1H-tetrazol-5-yl)methyl)amine hydrochloride(1340484-08-3)
• EPA Substance Registry System: (4,4-diphenylbut-3-en-1-yl)-((1H-tetrazol-5-yl)methyl)amine hydrochloride(1340484-08-3)

Safety Data

• Hazardous Substances Data: 1340484-08-3(Hazardous Substances Data)

Upstream product

• 1340483-93-3 (4,4-diphenylbut-3-en-1-yl)-[(1-(1,1,3,3-tetramethylbutyl)-1H-tetrazol-5-yl)methyl]amine 
• 93007-58-0 4,4-diphenylbut-3-en-1-ylamine 

Relevant articles and documents

Aminomethyltetrazoles as potential inhibitors of the c-aminobutyric acid transporters mGAT1-mGAT4: Synthesis and biological evaluation

1,5-Disubstituted and 5-monosubstituted aminomethyltetrazole derivatives derived from glycine were synthesized employing a TMSN3-modified variant of the Ugi reaction as a key step. All compounds were evaluated regarding their inhibitory potency and subtype selectivity at the four murine GABA transporter subtypes mGAT1-mGAT4. Though none of the 5-monosubstituted tetrazoles turned out to inhibit [3H]GABA uptake to a significant extent, the 1,5-disubstituted tetrazole derivatives displayed a distinct activity, especially at the GABA transport proteins mGAT2-mGAT4. Thus, a reasonable potent and selective inhibitor of mGAT3 was found. Additionally, two more compounds were identified as potent inhibitors of mGAT2. This is especially relevant, as up to date only few potent inhibitors of mGAT2 that do not affect mGAT1 are known.