134057-63-9Relevant academic research and scientific papers
Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives
Wrobel,Millen,Sredy,Dietrich,Gorham,Malamas,Kelly,Bauman,Harrison,Jones,Guinosso,Sestanj
, p. 2504 - 2520 (2007/10/02)
A series of aldose reductase inhibitors were prepared which were analogues of the potent, orally active inhibitor tolrestat (1). These compounds (5, 7, 9, and 10) have an extra substituent on one of the unoccupied positions on the naphthalene ring of 1. P
