1340591-73-2

Basic information

• Product Name: 2-(3,5-bis-trifluoromethyl-phenyl)-N-(1-ethyl-4-o-tolyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide
• Synonyms: 2-(3,5-bis-trifluoromethyl-phenyl)-N-(1-ethyl-4-o-tolyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide
• CAS NO: 1340591-73-2
• Molecular Weight: 548.531
• Mol File: 1340591-73-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3,5-bis-trifluoromethyl-phenyl)-N-(1-ethyl-4-o-tolyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-bis-trifluoromethyl-phenyl)-N-(1-ethyl-4-o-tolyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide(1340591-73-2)
• EPA Substance Registry System: 2-(3,5-bis-trifluoromethyl-phenyl)-N-(1-ethyl-4-o-tolyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide(1340591-73-2)

Safety Data

• Hazardous Substances Data: 1340591-73-2(Hazardous Substances Data)

Upstream product

• 289686-69-7 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride 
• 1340592-18-8 (4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-methyl-amine 
• 1340592-17-7 (4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-carbamic acid tert-butyl ester 
• 3528-58-3 5-Amino-1-ethylpyrazole 
• 30720-25-3 ethyl 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 
• 26823-99-4 [[(1-ethyl-5-pyrazolyl)amino]methylene]malonic acid diethyl ester 
• 59060-16-1 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 1340592-16-6 2-(3,5-bis-trifluoromethyl-phenyl)-N-(4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide 
• 16419-60-6 2-Methylphenylboronic acid 

Relevant articles and documents

PYRRAZOLOPYRIDINE DERIVATIVES

The present invention relates to a compound of formula (I), wherein R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, benzyl, -C(0)-lower alkyl, -C(0)-CH2-lower alkoxy, -C(0)-C3-6-cycloalkyl, -(CH2)°-C(0)-NR,R', -(CH2)°S(0)2- lower alkyl or -S(0)2-NR,R'; o is 0 or 1; R,R' are independently from each other hydrogen or lower alkyl, or may form together with the N atom to which they are attached a 5 or 6 membered heterocycloalkyl ring; R2 is hydrogen or lower alkyl; R3 is halogen, lower alkoxy, lower alkyl substituted by halogen or lower alkoxy substituted by halogen; and may be the same or different in case n is 2; n is 1 or 2; Ar is phenyl optionally substituted by one or two substituents selected from lower alkyl, halogen, lower alkoxy, lower alkyl substituted by hydroxy or cyano, or is a five or six membered heteroaryl group, selected from thiophenyl or pyridinyl which are optionally substituted by lower alkyl or halogen; or to a pharmaceutically active acid addition salt. It has surprisingly been found that the compounds of formula I show a high affinity simultaneously to both the NK1 and the NK3 receptors (dual NK1/NK3 receptor antagonists), useful in the treatment of schizophrenia.