3528-58-3

Basic information

• Product Name: 5-AMINO-1-ETHYLPYRAZOLE
• Synonyms: TIMTEC-BB SBB005554;ART-CHEM-BB B024267;1-ETHYL-1H-PYRAZOL-5-AMINE;2-ETHYL-2H-PYRAZOL-3-YLAMINE;AKOS B024267;5-AMINO-1-ETHYLPYRAZOLE;2-Amino-1-ethylpyrazole;5-Amino-1-ethylpyrazol
• CAS NO: 3528-58-3
• Molecular Formula: C₅H₉N₃
• Molecular Weight: 111.15
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrazoles
• Mol File: 3528-58-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 52-57 °C(lit.)
• Boiling Point: 92-94 °C0.01 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.0671 (rough estimate)
• Vapor Pressure: 0.042mmHg at 25°C
• Refractive Index: 1.5340 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.18±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-1-ETHYLPYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1-ETHYLPYRAZOLE(3528-58-3)
• EPA Substance Registry System: 5-AMINO-1-ETHYLPYRAZOLE(3528-58-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 3528-58-3(Hazardous Substances Data)

Usage

Uses

5-Amino-1-ethylpyrazole is a heterocyclic building block, has been used in the preparation of 1-protected-1H-pyrazolo[3,4-b]pyridines.

InChI:InChI=1/C5H9N3/c1-2-8-5(6)3-4-7-8/h3-4H,2,6H2,1H3

Upstream product

• 75-07-0 acetaldehyde 
• 353-07-1 3-hydrazinylpropanenitrile 
• 71-36-3 butan-1-ol 
• 107-13-1 acrylonitrile 
• 624-80-6 ethylhydrazine 
• 6162-76-1 cyanoacetaldehyde 
• 137968-12-8 1-(Ethylideneamino)pyrazole 
• 137968-19-5 1-(Ethylamino)pyrazole 
• 58793-47-8 1-ethyl-5-nitropyrazole 
• 42066-48-8 Acetaldehyd-N-(2-cyan-ethyl)-hydrazon 

Downstream Products

• 265324-42-3 2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-6-(2-ethyl-2H-pyrazol-3-ylcarbamoyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 868272-36-0 3-(5-cyano-6-(methylthio)pyrimidin-4-ylamino)-N-(1-ethyl-1H-pyrazol-5-yl)-4-methylbenzamide 
• 183151-34-0 N-(1-ethylpyrazol-5-yl)-4-methoxyanthranilic acid 
• 934062-76-7 1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid 
• 954261-91-7 6-cyclopropyl-1-ethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid 
• 261771-29-3 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 30720-25-3 ethyl 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 
• 41095-07-2 4-chloro-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 156302-62-4 5-<(Triphenylphosphoranylidene)amino>-1-ethylpyrazole 

Relevant articles and documents

PHOSPHODIESTARASE INHIBITORS

The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4 /PDE type 7 inhibitors. Compounds disclosed herein can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, f

Approach to the library of fused pyridine-4-carboxylic acids by combes-type reaction of acyl pyruvates and electron-rich amino heterocycles

A library of fused pyridine-4-carboxylic acids (including pyrazolo[3,4-b]pyridines, isoxazolo[5,4-b]pyridines, furo[2,3-b]pyridines, thieno[2,3-b]pyridines, and pyrido[2,3-d]pyrimidines) was generated by Combes-type reaction of acyl pyruvates and electron-rich amino heterocycles followed by hydrolysis of the ester. The library members were also demonstrated to undergo the standard combinatorial transformations including amide coupling and esterification, as well as less common heterocyclizations to 1,2,4-triazoles and 1,2,4-oxadiazoles.

PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS

The invention provides a compound of formula (I) or a salt thereof: wherein Ar has the sub-formula (x): and wherein: Q1 is NH or NMe, in which case Q2 is -C(O)-, -S(O)2-, -C(O)NH- or -C(O)NMe-; or Q1 is a bond o