1340599-26-9Relevant academic research and scientific papers
The Synthesis and Biological Evaluation of Anithiactin A/Thiasporine C and Analogues
Lamb, Richard A.,Badart, Michael P.,Swaney, Brooke E.,Gai, Sinan,Baird, Sarah K.,Hawkins, Bill C.
, p. 1829 - 1833 (2015)
The synthesis of anithiactin A has been achieved in four steps. Several closely related analogues were synthesised and their biological activity against colon and breast cancer cell lines evaluated. Anithiactin A was found not to be cytotoxic even at a hi
Concise synthesis of 2,4-disubstituted thiazoles from β-azido disulfides and carboxylic acids or anhydrides: Asymmetric synthesis of cystothiazole C
Liu, Yi,Sun, Xue,Zhang, Xing,Liu, Jun,Du, Yuguo
, p. 8453 - 8461 (2014/12/10)
A novel and efficient method for the one-pot synthesis of 2,4-disubstituted thiazoles from carboxylic acids or anhydrides is presented. Based on this new method, the total synthesis of the bis-2,4-disubstituted bis(thiazoles) natural product cystothiazole C is also presented. This journal is
Convenient Synthesis of Azolines to Azoles
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Paragraph 0102; 0105, (2013/03/26)
Azolines are oxidized in the presence of a copper-containing catalyst to azoles in the presence of molecular oxygen. A synthetic scheme converting azolines azoles is also provided.
Copper-catalyzed oxidation of azolines to azoles
Dawsey, Anna C.,Li, Vincent,Hamilton, Kimberly C.,Wang, Jianmei,Williams, Travis J.
, p. 7994 - 8002 (2012/08/08)
We report herein convenient, aerobic conditions for the oxidation of thiazolines to thiazoles and data regarding the oxidation mechanism. These reactions feature operationally simple and environmentally benign conditions and proceed in good yield to afford the corresponding azoles, thus enabling the inexpensive preparation of valuable molecular building blocks. Incorporation of a novel diimine-ligated copper catalyst, [(MesDABMe) CuII(OH2)3]2+ [-OTf] 2, provides increased reaction efficiency in many cases. In other cases copper-free conditions involving a stoichiometric quantity of base affords superior results.
