13406-98-9

Basic information

• Product Name: PIPERIDINE-1-CARBOXYLIC ACID
• Synonyms: PIPERIDINE-CARBOXYLIC ACID;PIPERIDINE-1-CARBOXYLIC ACID
• CAS NO: 13406-98-9
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.16
• Mol File: 13406-98-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PIPERIDINE-1-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: PIPERIDINE-1-CARBOXYLIC ACID(13406-98-9)
• EPA Substance Registry System: PIPERIDINE-1-CARBOXYLIC ACID(13406-98-9)

Safety Data

• Hazardous Substances Data: 13406-98-9(Hazardous Substances Data)

Usage

General Description

PIPERIDINE-1-CARBOXYLIC ACID, also known as norpipecolic acid, is a chemical compound with the molecular formula C6H11NO2. It is a cyclic secondary amine and a carboxylic acid, and is commonly used as a building block in organic synthesis and the production of pharmaceuticals. Piperidine-1-carboxylic acid is an important intermediate in the synthesis of drugs like piperidine and its derivatives, which are used in the treatment of various medical conditions. It is also used in the synthesis of pesticides, polymers, and other industrial chemicals. Piperidine-1-carboxylic acid has a wide range of applications in the pharmaceutical and chemical industries, making it a valuable and versatile compound.

Upstream product

• 2645-36-5 1-(N-phenylcarbamoyl)piperidine 
• 5325-94-0 N-Ethoxycarbonylpiperidine 
• 110-89-4 piperidine 
• 124-38-9 carbon dioxide 

Downstream Products

• 1796-27-6 piperidine-1-carboxylic acid methyl ester 
• 26250-84-0 (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid 
• 1103191-48-5 (2R,S)-1-cyano-phenylpiperidine-2-carboxylic acid 

Relevant articles and documents

Kinetics and mechanisms of gas phase elimination of ethyl 1-piperidine carboxylate, ethyl pipecolinate, and (revisited) ethyl 1-methyl pipecolinate

The kinetics of the gas-phase elimination of the title compounds has been determined in a static reaction system over the temperature range of 340-420°C and pressure range of 45-96 Torr. The reactions proved to be homogeneous, unimolecular, and obey a first-order rate law. The estimated rate coefficients are represented by the following Arrhenius expressions: Ethyl 1-piperidine carboxylate log k1 (S-1) = (12.61 ± 0.11) - (191.1 ± 1.4) kJ mol-1 (2.303 RT)-1, r = 0.9999 Ethyl pipecolinate log k1 (S-1) = (12.87 ± 0.16) - (204.3 ± 2.1) kJ mol-1 (2.303 RT)-1, r = 0.9998 Ethyl 1-methyl pipecolinate log k1 (S-1) = (13.34 ± 0.32) - (209.4 ± 4.0) kJmol-1 (2.303 RT) -1, r = 0.9992 The first step of decomposition of these esters is the formation of the corresponding carboxylic acids and ethylene. The acid intermediate undergoes a very fast decarboxylation process. The mechanism of this elimination reactions is suggested on the basis of the kinetic and thermodynamic parameters.

Highly efficient and selective formation of hydrogencarbonate in CO 2 absorption process using piperidine and piperazine derivatives

This investigation demonstrated that bicarbonate ions were selectively formed over carbamate in a CO2 absorption process using piperidine and piperazine derivatives based on 13CNMR. Piperidines with methyl or hydroxymethyl substituent at 2 position (PiP-Me and PiP-MeOH) and 2,5-dimethylpiperazine (DM-PiZ) generated the bicarbonate ions as main adducts in reaction with CO2. The absorptions of CO2 by those aqueous amines (PiP-Me and DM-PiZ) were faster than those of MEA (2-aminoethanol).

Cyclic hydroxamic acids as metalloproteinase inhibitors

The present application de gibes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NRa, and S(O)p, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease inhibitors.