134073-79-3

Basic information

• Product Name: N-(2-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-N-[3-(1-pyrrolidinyl)propyl]amine
• Synonyms: N-(2-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-N-[3-(1-pyrrolidinyl)propyl]amine
• CAS NO: 134073-79-3
• Molecular Formula: C21H25ClN2S
• Molecular Weight: 372.9546
• Mol File: 134073-79-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-N-[3-(1-pyrrolidinyl)propyl]amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-N-[3-(1-pyrrolidinyl)propyl]amine(134073-79-3)
• EPA Substance Registry System: N-(2-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-N-[3-(1-pyrrolidinyl)propyl]amine(134073-79-3)

Safety Data

• Hazardous Substances Data: 134073-79-3(Hazardous Substances Data)

Upstream product

• 23159-07-1 3-(1-pyrrolidinyl)propylamine 
• 4925-65-9 2,10-dichloro-10,11-dihydrodibenzothiepin 
• 26165-45-7 3-(pyrrolidin-1-yl)propanenitrile 

Relevant articles and documents

POTENTIAL ANTIDEPRESSANTS: 10-AMINO-2-CHLORO-10,11-DIHYDRODIBENZOTHIEPINS

Reduction of N-(2-chloro-10,11-dihydrodibenzothiepin-10-yl)formamide with lithium aluminium hydride resulted in the methylamino compound IV.The dimethylamino compound V was obtained by methylation of 10-amino-2-chloro-10,11-dihydrodibenzothiepin with formic acid and aqueous formaldehyde.Substitution reactions of 2,10-dichloro-10,11-dihydrodibenzothiepin with a series of primary and secondary amines afforded the title compounds VI to XXVIII.The bases were transformed to salts and pharmacologically tested.Only the pyrrolidino compound IX (hydrogen succinate VUFB-15551) showed a clear pharmacological profile of a potential antidepressant.