134079-01-9

Upstream product

• 1193-55-1 2-methylcyclohexane-1,3-dione 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 

Downstream Products

• 154194-02-2 4a-Hydroxy-9a-methyl-2,3,4,4a,9,9a-hexahydro-fluoren-1-one 
• 138536-52-4 2-(2-Oxo-cyclohexylmethyl)-benzoic acid ethyl ester 
• 138536-51-3 (4bS,8aR)-4b-Hydroxy-4b,5,6,7,8,9-hexahydro-fluorene-8a-carboxylic acid ethyl ester 
• 134109-80-1 6-(2-Bromobenzyl)-6-methyl-5-oxocyclohex-1-en-1-yl triflate 

Relevant academic research and scientific papers

Nickel-catalyzed intramolecular desymmetrization addition of aryl halides to 1,3-diketones

A nickel-catalyzed intramolecular addition of aryl halides to 1,3-diketones was first developed. This desymmetrization reaction afforded polycyclic products bearing two tetrasubstituted centers with excellent diastereoselectivities and high yields. Moderate enantioselectivities were achieved in the presence of a chiral ligand. This transformation has great potential for the synthesis of polycyclic compounds including spiro[4,4,3,0] compounds. This journal is

Enantioselective Palladium-Catalyzed Intramolecular α-Arylative Desymmetrization of 1,3-Diketones

An efficient enantioselective protocol has been reported to build highly oxygenated and densely substituted bicyclo[m.n.1] skeletons through intramolecular asymmetric α-arylative desymmetrization of 1,3-diketones. Employing Pd catalyst and FOXAP ligand, various bicyclo[m.n.1] skeleton with different size can be accessed with high enantio- and diastereoselectivities. Utilizing the present method as a key step, formal asymmetric total synthesis of the (-)-parvifoline has been demonstrated.

The Use of R3SiSnR'3 in Organic Synthesis. A Novel Palladium-Catalyzed Tandem Transmetalation-Cyclization Reaction

The intramolecular coupling of vinyl triflates 12 with vinyl halides proceeded smoothly in the presence of Bu3SnSiMe3 (1a) and a palladium catalyst and gave cyclic products 13 via tandem intermolecular and intramolecular transmetalations.