134107-69-0

Usage

Uses

Used in Pharmaceutical Research:
Boc-D-4-Thiazolylalanine is used as a building block in the synthesis of peptides for various pharmaceutical applications. Its unique properties allow for the creation of peptides with enhanced biological activity and stability, making it an essential component in the development of new drugs and therapeutic agents.
Used in Peptide Synthesis:
In the field of peptide synthesis, Boc-D-4-Thiazolylalanine is used as a key component to construct peptides with specific functionalities. The Boc protecting group ensures that the amino acid can be incorporated into peptide chains without unwanted side reactions, facilitating the synthesis of complex peptide structures.
Used in Drug Development:
Boc-D-4-Thiazolylalanine is used as a crucial element in the development of peptide-based drugs. Its ability to modify the structure and properties of peptides contributes to the creation of drugs with improved pharmacokinetics, pharmacodynamics, and therapeutic efficacy.
Used in Medicinal Chemistry:
In medicinal chemistry, Boc-D-4-Thiazolylalanine is employed as a versatile tool for the design and synthesis of bioactive peptides. Its unique chemical structure and properties make it an invaluable resource for exploring new therapeutic targets and developing innovative drug candidates.
Used in Drug Discovery:
Boc-D-4-Thiazolylalanine plays a significant role in drug discovery, where it is used to identify and optimize potential drug candidates. Its incorporation into peptides can lead to the discovery of novel bioactive compounds with promising therapeutic potential.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 134038-93-0 4-<(R)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinone>methylthiazole 
• 134038-92-9 1-<(R)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinone>-3-chloro-2-propanone 

Downstream Products

• 131896-42-9 (2R)-2-amino-3-(thiazol-4-yl)propanoic acid 
• 1416469-39-0 tert-butyl [(2R)-1-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl]piperidin-1-yl}-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]carbamate 
• 1416469-40-3 (4aS,8aR)-2-{1-[(2R)-2-amino-3-(1,3-thiazol-4-yl)propanoyl]piperidin-4-yl}-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one hydrochloride 
• 1416467-86-1 4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl]piperidin-1-yl}-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide 
• 134362-80-4 [1-(R)-(1-(S)-cyclohexylmethyl-3-cyclopropyl-2-(R),3(S)-dihydroxy-propylcarbamoyl)-thiazol-4-yl-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

ENCAPSULATED RENIN INHIBITOR COMPOSITION

A pharmaceutical composition comprising a solution of a tenin inhibitor of the formula: STR1 wherein R 1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-1-oxo-4-piperazinyl, 2-oxo-4-piperazinyl, 4-morpholinyl, 4-thiomorpholinyl or 1-methyl-4-homopiperazinyl; R 2 is benzyl, p-methoxybenzyl, 2-phenylethyl, 1-naphthylmethyl or 2-naphthylmethyl;R 3 is 4-thiazolyl, 2-amino-4-thiazolyl, 2-thiazolyl, 5-thiazolyl, 1-pyrazolyl, 3-pyrazolyl, 1-imidazolyl, n-propyl, isopropyl, CH 3 S--or CH 3 SCH 2--;R 4 is loweralkyl or cyclopropyl;R 5 is hydrogen or loweralkyl; andX is CH 2 or NH; or a pharmaceutically acceptable salt, ester or prodrug thereof in a pharmaceutically acceptable solvent, said solution being encapsulated in a soft elastic gelatin capsule.

Psoriasis treatment

The present invention relates to the use of renin inhibitors and to renin inhibitor compositions for treatment of psoriasis.

Synthesis of N-(tert-Butoxycarbonyl)-3-(4-thiazolyl)-L-alanine

Efficient syntheses of N-(tert-butoxycarbonyl)-3-(4-thiazolyl)-L-alanine (11) are described.