1341126-12-2

Upstream product

• 487-68-3 mesytaldehyde 
• 1600503-70-5 potassium 2-pyridinyl sulfonyl-difluoroacetate 
• 4028-63-1 iodomesitylene 

Downstream Products

• 1262431-31-1 (E)-2-(2-fluorovinyl)-1,3,5-trimethylbenzene 

Relevant academic research and scientific papers

Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine

A key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na-Ph3P with aldehydes was synthesized and characterized, which confirmed the reaction mechanism. The decarboxylation of this stable intermediate was a convenient approach for Wittig difluroolefination. Its reactivity could be adjusted by the modification of the substituent on the phosphorus.

Synthesis and Derivatization of 1,1-[18F]Difluorinated Alkenes

A general method for the synthesis of 1,1-[18F]difluorinated alkenes from [18F]fluoride is reported. This transformation is highly regioselective giving the desired 18F-fluoroalkenes with radiochemical purities of up to 77 % within 20 minutes and a molar activity (Am) of 1 GBq μmol?1. The transformations are operationally simple to perform and were readily translated onto a commercial automated synthesis unit. The resultant 1,1-[18F]difluorinated alkene motif is prevalent in numerous drug molecules, and this is the first general method to synthesize this motif with fluorine-18. 18F-fluorinated alkenes are excellent building blocks and participate in a number of post-labeling transformations to access a range of 18F-perfluorinated functional groups that have never before been radiolabeled with non-carrier-added [18F]fluoride. This method considerably expands the range of 18F-motifs accessible to radiochemists.

Decarboxylative julia-kocienski gem-difluoro-olefination of 2-pyridinyl sulfonyldifluoroacetate

The decarboxylation of potassium 2-pyridinyl sulfonyldifluoroacetate and its subsequent reaction with aldehydes was found to be an efficient approach for the Julia-Kocienski reaction under mild conditions to give gem-difluoro olefins in moderate to excell

Decarboxylative Julia-Kocienski gem-Difluoro-Olefination of 2-Pyridinyl Sulfonyldifluoroacetate

The decarboxylation of potassium 2-pyridinyl sulfonyldifluoroacetate and its subsequent reaction with aldehydes was found to be an efficient approach for the Julia-Kocienski reaction under mild conditions to give gem-difluoro olefins in moderate to excellent yields. Owing to its high stability in the pure state and its easy decarboxylation in polar solvents, potassium 2-pyridinyl sulfonyldifluoroacetate is expected to be an efficient gem-difluoro-olefination reagent. The decarboxylation of potassium 2-pyridinyl sulfonyldifluoroacetate and its subsequent reaction with aldehydes is an efficient approach for the Julia-Kocienski reaction under mild conditions to give gem-difluoro olefins in moderate to excellent yields.

Facile synthesis of β,β-difluorostyrenes via the negishi coupling of thermally stable 2,2-difluorovinyl zincTMEDA complex

2,2-Difluorovinylzinc chlorideTMEDA complex, readily prepared from 1,1-difluoroethylene, undergoes the palladiumcatalyzed coupling reaction with aryl halides to afford β,β- difluorostyrenes in high yield. This reaction not only proceeds smoothly with ster