Cas 1341198-45-5,4-(4-fluorophenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

1341198-45-5

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Basic information

Product Name: 4-(4-fluorophenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester
Synonyms: 4-(4-fluorophenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester
CAS NO:1341198-45-5
Molecular Formula:
Molecular Weight: 248.257
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 4-(4-fluorophenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester(CAS DataBase Reference)
NIST Chemistry Reference: 4-(4-fluorophenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester(1341198-45-5)
EPA Substance Registry System: 4-(4-fluorophenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester(1341198-45-5)

Safety Data

Hazard Codes: N/A
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Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1341198-45-5(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1341198-45-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,1,1,9 and 8 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1341198-45:
(9*1)+(8*3)+(7*4)+(6*1)+(5*1)+(4*9)+(3*8)+(2*4)+(1*5)=145
145 % 10 = 5
So 1341198-45-5 is a valid CAS Registry Number.

1341198-45-5Upstream product

1341198-45-5Downstream Products

1341198-39-7 4-(4-fluorophenyl)-5-methyl-2H-pyrazole-3-carboxylic acid

1341198-45-5Relevant academic research and scientific papers

Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain l-2-hydroxy acid oxidase

Barawkar, Dinesh A.,Bandyopadhyay, Anish,Deshpande, Anil,Koul, Summon,Kandalkar, Sachin,Patil, Pradeep,Khose, Goraksha,Vyas, Samir,Mone, Mahesh,Bhosale, Shubhangi,Singh, Umesh,De, Siddhartha,Meru, Ashwin,Gundu, Jayasagar,Chugh, Anita,Palle, Venkata P.,Mookhtiar, Kasim A.,Vacca, Joseph P.,Chakravarty, Prasun K.,Nargund, Ravi P.,Wright, Samuel D.,Roy, Sophie,Graziano, Michael P.,Cully, Doris,Cai, Tian-Quan,Singh, Sheo B.

, p. 4341 - 4347 (2012/07/17)

Long chain l-2-hydroxy acid oxidase 2 (Hao2) is a peroxisomal enzyme expressed in the kidney and the liver. Hao2 was identified as a candidate gene for blood pressure (BP) quantitative trait locus (QTL) but the identity of its physiological substrate and its role in vivo remains largely unknown. To define a pharmacological role of this gene product, we report the development of selective inhibitors of Hao2. We identified pyrazole carboxylic acid hits 1 and 2 from screening of a compound library. Lead optimization of these hits led to the discovery of 15-XV and 15-XXXII as potent and selective inhibitors of rat Hao2. This report details the structure activity relationship of the pyrazole carboxylic acids as specific inhibitors of Hao2.

Potent and selective inhibitors of long chain l-2-hydroxy acid oxidase reduced blood pressure in DOCA salt-treated rats

Barawkar, Dinesh A.,Meru, Ashwin,Bandyopadhyay, Anish,Banerjee, Abir,Deshpande, Anil M.,Athare, Chandrashekhar,Koduru, Chandrasekhar,Khose, Goraksha,Gundu, Jayasagar,Mahajan, Koshu,Patil, Pradeep,Kandalkar, Sachin R.,Niranjan, Sanjay,Bhosale, Shubhangi,De, Siddhartha,Mukhopadhyay, Sudit,Chaudhary, Sumit,Koul, Summon,Singh, Umesh,Chugh, Anita,Palle, Venkata P.,Mookhtiar, Kasim A.,Vacca, Joseph,Chakravarty, Prasun K.,Nargund, Ravi P.,Wright, Samuel D.,Roy, Sophie,Graziano, Michael P.,Singh, Sheo B.,Cully, Doris,Cai, Tian-Quan

, p. 919 - 923 (2012/02/15)

l-2-Hydroxy acid oxidase (Hao2) is a peroxisomal enzyme with predominant expression in the liver and kidney. Hao2 was recently identified as a candidate gene for blood pressure quantitative trait locus in rats. To investigate a pharmacological role of Hao

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