1341200-82-5 Usage
Chemical compound
2,5-dichloro-N-(4-chloro-2-(pyrrolidin-1-ylsulfonyl)phenyl)pyrimidin-4-amine
Class
Pyrimidine-based inhibitor of dihydroorotate dehydrogenase (DHODH)
Role
Inhibitor of DHODH, an enzyme in the de novo pyrimidine biosynthesis pathway
Therapeutic potential
Studied for use in cancer therapy, anti-inflammatory, and immunosuppressive properties
Preclinical studies
Showing promising results
Current investigations
Potential therapeutic use in cancer and autoimmune disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 1341200-82-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,1,2,0 and 0 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1341200-82:
(9*1)+(8*3)+(7*4)+(6*1)+(5*2)+(4*0)+(3*0)+(2*8)+(1*2)=95
95 % 10 = 5
So 1341200-82-5 is a valid CAS Registry Number.
1341200-82-5Relevant articles and documents
Design, synthesis, and biological evaluation of a series of novel AXL kinase inhibitors
Mollard, Alexis,Warner, Steven L.,Call, Lee T.,Wade, Mark L.,Bearss, Jared J.,Verma, Anupam,Sharma, Sunil,Vankayalapati, Hariprasad,Bearss, David J.
, p. 907 - 912 (2012/01/19)
The receptor tyrosine kinase AXL has emerged in recent years as an potential oncology target due to its overexpression in several types of cancers coupled with its ability to promote tumor growth and metastasis. To identify small molecule inhibitors of AXL, we built a homology model of its catalytic domain to virtually screen and identify scaffolds displaying an affinity for AXL. Further computational and structure-based design resulted in the synthesis of a series of 2,4,5-trisubstitued pyrimidines, which demonstrated potent inhibition of AXL in vitro (IC50 = 19 nM) and strongly inhibited the growth of several pancreatic cell lines.
