1341230-20-3

Basic information

• Product Name: C₁₈H₁₇FO₃
• Synonyms: C₁₈H₁₇FO₃
• CAS NO: 1341230-20-3
• Molecular Weight: 300.33
• Mol File: 1341230-20-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₇FO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₇FO₃(1341230-20-3)
• EPA Substance Registry System: C₁₈H₁₇FO₃(1341230-20-3)

Safety Data

• Hazardous Substances Data: 1341230-20-3(Hazardous Substances Data)

Upstream product

• 1341230-18-9 C₁₅H₁₃FO₂ 
• 106-89-8 epichlorohydrin 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 1431-92-1 5′-fluoro-2′-hydroxychalcone 
• 100-52-7 benzaldehyde 

Downstream Products

• 1341229-72-8 C₂₉H₃₁FN₂O₄*ClH 
• 1341228-60-1 C₂₅H₂₆FNO₃*ClH 
• 1341228-64-5 C₂₇H₃₀FNO₃*ClH 
• 1341228-68-9 C₃₀H₄₀FNO₃*ClH 
• 1341228-65-6 C₂₂H₂₈FNO₃*ClH 
• 1341228-67-8 C₂₆H₃₆FNO₃*ClH 
• 1341228-66-7 C₂₄H₃₂FNO₃*ClH 
• 1341228-63-4 C₃₁H₃₀FNO₄*ClH 
• 1341228-62-3 C₃₁H₃₀FNO₃*ClH 
• 1341228-61-2 C₃₁H₃₀FNO₃*ClH 
• 1341229-63-7 C₂₉H₃₁ClFNO₄*ClH 

Relevant articles and documents

Optimization of propafenone analogues as antimalarial leads

Propafenone, a class Ic antiarrythmic drug, inhibits growth of cultured Plasmodium falciparum. While the drug's potency is significant, further development of propafenone as an antimalarial would require divorcing the antimalarial and cardiac activities as well as improving the pharmacokinetic profile of the drug. A small array of propafenone analogues was designed and synthesized to address the cardiac ion channel and PK liabilities. Testing of this array revealed potent inhibitors of the 3D7 (drug sensitive) and K1 (drug resistant) strains of P. falciparum that possessed significantly reduced ion channel effects and improved metabolic stability. Propafenone analogues are unusual among antimalarial leads in that they are more potent against the multidrug resistant K1 strain of P. falciparum compared to the 3D7 strain.