134136-74-6

Basic information

• Product Name: 2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone
• Synonyms: 2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone
• CAS NO: 134136-74-6
• Molecular Weight: 495.778
• Mol File: 134136-74-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone(134136-74-6)
• EPA Substance Registry System: 2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone(134136-74-6)

Safety Data

• Hazardous Substances Data: 134136-74-6(Hazardous Substances Data)

Upstream product

• 51135-96-7 4-benzyl-4-hydroxypiperidine 
• 134136-66-6 4-(triisopropylsilyloxy)-alpha-bromopropiophenone 
• 70-70-2 4-hydroxypropiophenone 
• 134136-88-2 1-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)propan-1-one 
• 13154-24-0 triisopropylsilyl chloride 

Relevant articles and documents

2-PIPERIDINO-1-ALKANOL DERIVATIVES AS NEUROPROTECTIVE AGENTS

A method of blocking N-methyl-D-aspartic acid (NMDA) receptor sites in a mammal in need thereof with an effective NMDA blocking (neuroprotective and antiischemic) amount of 2-piperidino-1-alkanol derivatives and 2-azabicyclo-1-alkanol derivatives and analogs and pharmaceutically acceptable salts thereof; methods of using these compounds in the treatment of stroke, spinal cord trauma, traumatic brain injury, multiinfarct dementia, CNS degenerative diseases such as Alzheimer's disease, senile dementia of the Alzheimer's type, Huntington's disease, Parkinson's disease, epilepsy, amyotrophic lateral sclerosis, pain, AIDS dementia, psychotic conditions, drug addictions, migraine, hypoglycemia, anxiolytic conditions, urinary incontinence and an ischemic event arising from CNS surgery, open heart surgery or any procedure during which the function of the cardiovascular system is compromised.

Nortropyl-1-alkanol derivatives as antiischemic agents

2-(8-Azabicyclo[3.2.1]oct-8-yl)alkanols of the formula STR1 wherein Q is S or CH=CH; X is H, OH or another aromatic substituent; R is hydrogen, alkyl, alkenyl or alkynyl; Y and Y1 are taken together and are arylmethylene or aralkylmethylene (or a corresponding epoxy derivative) or Y and Y1 are taken separately and Y is hydrogen or OH, and Y1 is aryl, aralkyl, arylthio, or aryloxy; and structurally related 2-(piperidino)alkanols; pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds.