146346-83-0Relevant academic research and scientific papers
Divergent and site-selective solid-phase synthesis of sulfopeptides
Taleski, Deni,Butler, Stephen J.,Stone, Martin J.,Payne, Richard J.
, p. 1316 - 1320 (2013/01/11)
On solid ground: A solid-phase strategy for the efficient synthesis of sulfopeptides is described. Selective deprotection of orthogonally-protected tyrosine residues and solid-phase sulfation provided divergent access to differentially sulfated peptides in high yields. Copyright
Application of t-Butyldimethylsilyl Ethers of Serine, Threonine and Tyrosine in Peptide Synthesis
Fischer, Peter M.
, p. 7605 - 7608 (2007/10/02)
The utility of Tbdms (t-butyldimethylsilyl) ethers, prepared conveniently in a one pot procedure from Nα-Fmoc (9-fluorenylmethoxycarbonyl) and Nα-Z (benzyloxycarbonyl) hydroxyamino acids, is demonstrated: peptide bond formation and esterification to 4-alkoxybenzylalcohol resin are achieved readily with these derivatives.The lability of the Tbdms ethers to various reagents enables selective deprotection of the hydroxyl side-chains assembly, desirable, e.g., for phosphorylation of glycosylation.
