132018-15-6Relevant academic research and scientific papers
A Short and Facile Synthetic Route to Hydroxylated Flavones. New Syntheses of Apigenin, Tricin, and Luteolin
Nagarathnam, Dhanapalan,Cushman, Mark
, p. 4884 - 4887 (2007/10/02)
Reaction of lithium polyanions generated from o-hydroxyacetophenones 3a-f with O-silyloxylated benzoates 2a-d gave 1-aryl-3-(2-hydroxyphenyl)-1,3-propanediones 4a-n, which on treatment with acetic acid containing 0.5percent H2SO4 at 95 - 100 deg C afforded hydroxylated flavones 5-18 in high yields (76 - 92percent).
Synthesis and Protein-Tyrosine Kinase Inhibitory Activities of Flavanoid Analogues
Cushman, Mark,Nagarathnam, Dhanapalan,Burg, Debra L.,Geahlen, Robert L.
, p. 798 - 806 (2007/10/02)
Treatment of o-hydroxyacetophenones 2a-e with excess lithium bis(trimethylsilyl)amide followed by dialkyl carbonates gave 3-(2-hydroxyaryl)-3-oxopropanoates 3a-e.The latter substances were transformed through the reaction of their magnesium chelates with
