134186-71-3 Usage
Chemical Family
1H-Indole, 1-(3-chloropropyl)belongs to the indole family, which is a class of heterocyclic compounds.
Structure
The compound contains a three-carbon propyl chain with a chlorine atom attached to it.
Relevance
It is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds.
Selective Functionalization
The compound has potential for selective functionalization and derivatization, making it a valuable building block for the development of various chemical and pharmaceutical products.
Biological Activities
It has been studied for its biological activities and potential applications in medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 134186-71-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,1,8 and 6 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 134186-71:
(8*1)+(7*3)+(6*4)+(5*1)+(4*8)+(3*6)+(2*7)+(1*1)=123
123 % 10 = 3
So 134186-71-3 is a valid CAS Registry Number.
134186-71-3Relevant academic research and scientific papers
Watanabe, Kenji,Ohshima, Takashi
, p. 3959 - 3964 (2018)
A benzylic substitution of 3-indolyl(hydroxyl)acetate derivatives with thiols proceeded specifically in the presence of amino, carboxy, and phosphate groups in weakly acidic aqueous solutions under nearly physiological condition, while no reaction occurred at pH over 7. Kinetic studies revealed that the reaction followed second-order kinetics (first-order in the reactant and first-order in thiol) in contrast with the SN1 mechanism of common benzylic substitution of alcohols. The utility of the present method for functionalization of biomacromolecules was demonstrated using several model proteins, such as lysozyme, insulin, trypsin, and serum albumin. The catalytic bioactivity of lysozyme in lysis of Micrococcus lysodeikticus cells was completely retained after the modification.
