134219-01-5Relevant academic research and scientific papers
Synthesis of potential UDP-glucuronosyltransferase inhibitors containing a diphosphate function
Noort, D.,Marel, G. A. van der,Gen, A. van der,Mulder, G. J.,Boom, J. H. van
, p. 53 - 56 (2007/10/02)
The synthesis of potential inhibitors of UDP-glucuronosyltransferase, in which the β-phosphate moiety of uridine 5'-diphosphate is linked to phenolic or alcoholic hydroxyl groups, is described.Key intermediates in the formation of the diphosphate function are S-(4-methylphenyl) 2-cyanoethyl phosphorothioate triesters which, after conversion into the corresponding S-(4-methylphenyl) phosphorothioate diesters, react with phosphate monoesters, in the presence of iodine, to give the target molecules.
