134227-60-4

Basic information

• Product Name: 2-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1,3-oxazole
• Synonyms: 2-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1,3-oxazole
• CAS NO: 134227-60-4
• Molecular Weight: 257.719
• Mol File: 134227-60-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1,3-oxazole(134227-60-4)
• EPA Substance Registry System: 2-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1,3-oxazole(134227-60-4)

Safety Data

• Hazardous Substances Data: 134227-60-4(Hazardous Substances Data)

Upstream product

• 39887-24-6 N-(2-phenylethyl)-p-chlorobenzamide 
• 537711-21-0 (4-chlorophenyl)(2-phenylaziridin-1-yl)methanone 
• 100-42-5 styrene 
• 21368-28-5 4-chlorobenzoyl azide 
• 104-88-1 4-chlorobenzaldehyde 
• 7568-93-6 2-Amino-1-phenylethanol 
• 132401-91-3 3-(4-chlorophenyl)-1,4,2-dioxazol-5-one 

Relevant articles and documents

Visible light bromide catalysis for oxazoline, pyrrolidine, and dihydrooxazine synthesesviaCsp3-H functionalizations

A catalytic benzylic Csp3-H functionalization protocol is described here. This visible light-mediated process is centered on the utilization of a bromide catalyst and oxidant to generate a nitrogen (N)-centered radical for a site-selective hydrogen atom transfer (HAT) process. This strategy enabled the unconventional syntheses of a number of N-heterocycles dependent on the amide identity. We also discovered a nucleophilicity-dependent kinetic resolution for stereochemical differentiation of Csp3-H bonds that enabled the stereoselective synthesis ofcis- andtrans-oxazolines.

Use of Hypervalent Iodine in the Synthesis of Isomeric Dihydrooxazoles

[Figure not available: see fulltext.] A convenient synthesis of 2- and/or 3-oxazolines has been developed depending on the structure and stereochemistry of the starting amino alcohol. PhI(OAc)2 acted as oxidant on the intermediate imine, as sup