1342276-76-9 Usage
Description
1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea, also known as RKI-1313, is a compound that acts as an inhibitor of Rho-associated kinase 1 (ROCK1) and 2 (ROCK2) with respective IC50s of 34 and 8 μM. It is characterized by its ability to modulate the activity of ROCK proteins, which play a crucial role in various cellular processes, including cell migration, proliferation, and survival.
Uses
Used in Pharmaceutical Research:
1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea is used as a research tool for studying the role of ROCK proteins in various biological processes and diseases. Its ability to inhibit ROCK1 and ROCK2 makes it a valuable compound for investigating the molecular mechanisms underlying these processes and for identifying potential therapeutic targets.
Used in Drug Development:
In the pharmaceutical industry, RKI-1313 is used as a starting point for the development of new drugs targeting ROCK proteins. Its inhibitory properties can be leveraged to design more potent and selective ROCK inhibitors with improved pharmacological profiles, which could potentially be used in the treatment of various diseases associated with ROCK hyperactivation.
Used as a Negative Control:
1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea is also used as a negative control for the ROCK inhibitor RKI-1447. This allows researchers to compare the effects of RKI-1447 with those of a structurally similar compound that does not exhibit the same level of ROCK inhibition, thereby providing a better understanding of the specific activities and potential side effects of RKI-1447.
Check Digit Verification of cas no
The CAS Registry Mumber 1342276-76-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,2,2,7 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1342276-76:
(9*1)+(8*3)+(7*4)+(6*2)+(5*2)+(4*7)+(3*6)+(2*7)+(1*6)=149
149 % 10 = 9
So 1342276-76-9 is a valid CAS Registry Number.
1342276-76-9Relevant articles and documents
Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)
Pireddu, Roberta,Forinash, Kara D.,Sun, Nan N.,Martin, Mathew P.,Sung, Shen-Shu,Alexander, Brian,Zhu, Jin-Yi,Guida, Wayne C.,Sch?nbrunn, Ernst,Sebti, Sa?d M.,Lawrence, Nicholas J.
, p. 699 - 709 (2013/11/06)
Potent ROCK inhibitors of a new class of 1-benzyl-3-(4-pyridylthiazol-2-yl) ureas have been identified. Remarkable differences in activity were observed for ureas bearing a benzylic stereogenic center. Derivatives with hydroxy, methoxy and amino groups at the meta position of the phenyl ring give rise to the most potent inhibitors (low nM). Substitutions at the para position result in substantial loss of potency. Changes at the benzylic position are tolerated resulting in significant potency in the case of methyl and methylenehydroxy groups. X-Ray crystallography was used to establish the binding mode of this class of inhibitors and provides an explanation for the observed differences of the enantiomer series. Potent inhibition of ROCK in human lung cancer cells was shown by suppression of the levels of phosphorylation of the ROCK substrate MYPT-1.
