1342295-76-4Relevant academic research and scientific papers
Enantioselective Spirocyclopropanation of para-Quinone Methides Using Ammonium Ylides
Roiser, Lukas,Waser, Mario
, p. 2338 - 2341 (2017)
The use of Cinchona alkaloid-based chiral ammonium ylides allows for the first highly enantioselective and broadly applicable spirocyclopropanation reactions of para-quinone methides. This strategy provides a straightforward protocol toward the chiral spiro[2.5]octa-4,7-dien-6-one skeleton, which is a frequently found structural motif in important biologically active molecules.
Identification of the best-suited leaving group for the diastereoselective synthesis of glycidic amides from stabilised ammonium ylides and aldehydes
Herchl, Richard,Stiftinger, Martin,Waser, Mario
supporting information; experimental part, p. 7023 - 7027 (2011/11/04)
In comparison to the use of sulfur ylides, the use of ammonium ylides for the synthesis of epoxides is significantly less developed. As a part of our systematic investigations concerning the use of amide-stabilised ammonium ylides for the synthesis of glycidic amides we have focused on the identification of the best-suited amino leaving group for this purpose. Whereas tertiary amines like quinuclidine or cinchona alkaloids were found to be not suited for epoxide formation, trimethylamine was found to be the leaving group of choice, yielding trans-glycidic amides in excellent yields of > 90%.
