134245-03-7Relevant academic research and scientific papers
ENANTIOSELECTIVE ACYLATION OF A BETA-LACTAM INTERMEDIATE IN THE SYNTHESIS OF LORACARBEF USING PENICILIIN G AMIDASE
Zmijewski, Milton J.,Briggs, Barbara S.,Thompson, Allen R.,Wright, Ian G.
, p. 1621 - 1622 (1991)
Penicillin G amidase from E. coli has been shown to selectively acylate, in an efficient manner, the (2R,3S) isomer of a cis, racemic azetidinone intermediate used in a synthesis of loracarbef, a carbacephalosporin antibiotic.The acylation occurs using methyl phenylacetate (MPA) and using methyl phenoxyacetate (MPOA) as the acylating agents.The enzyme displays similar enantioselectivity with MPOA or MPA.
