Tetrahedron Letters p. 1621 - 1622 (1991)
Update date:2022-08-04
Topics: Characterization Workup Reaction Conditions Enzyme Selection Substrate Preparation Enzymatic Acylation
Zmijewski, Milton J.
Briggs, Barbara S.
Thompson, Allen R.
Wright, Ian G.
Penicillin G amidase from E. coli has been shown to selectively acylate, in an efficient manner, the (2R,3S) isomer of a cis, racemic azetidinone intermediate used in a synthesis of loracarbef, a carbacephalosporin antibiotic.The acylation occurs using methyl phenylacetate (MPA) and using methyl phenoxyacetate (MPOA) as the acylating agents.The enzyme displays similar enantioselectivity with MPOA or MPA.
View MoreBeijing Century Richap Chemistry Co.,Ltd
Contact:+86- 010-64455497
Address:Guannan County, Lianyungang City, Jiangsu Province, China
Shandong Ailitong New Material Co.,Ltd
Contact:+86-536-3226266
Address:zhongjia village, putong town , qingzhou city,Shandong Province,China
Contact:Tel: +86-25-58353800
Address:23 Lijing Road, Nanjing Hi-Tech Zone, Nanjing, Jiangsu, China, 210061
jintan yufan Medicine Raw materials Co.,Ltd.(expird)
Contact:86-519-82808282
Address:6th,Jincheng Huangzhuang
website:http://www.hybio.com.cn
Contact:+86 755 26588093
Address:No.9 Linkong West Street, Hengdian Street, Huangpi District, Wuhan City, China.
Doi:10.1016/j.bioorg.2020.103643
(2020)Doi:10.1016/j.bmc.2010.10.023
(2010)Doi:10.1021/ac50098a014
(1935)Doi:10.1021/jm800244v
(2008)Doi:10.1021/jm3007323
(2012)Doi:10.1021/ol701464j
(2007)
