134271-94-6

Basic information

• Product Name: 3-methyl-4-nitro-1H-indole
• Synonyms: 3-methyl-4-nitro-1H-indole;1H-Indole, 3-Methyl-4-nitro-
• CAS NO: 134271-94-6
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176
• Mol File: 134271-94-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.355
• CAS DataBase Reference: 3-methyl-4-nitro-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-4-nitro-1H-indole(134271-94-6)
• EPA Substance Registry System: 3-methyl-4-nitro-1H-indole(134271-94-6)

Safety Data

• Hazardous Substances Data: 134271-94-6(Hazardous Substances Data)

Usage

General Description

3-methyl-4-nitro-1H-indole is a chemical compound with the molecular formula C9H8N2O2. It is a nitro-substituted indole derivative, which is commonly used in the pharmaceutical industry for the synthesis of various bioactive compounds. This chemical is known for its characteristic yellow crystalline appearance and is a member of the indole family, which are aromatic heterocyclic compounds. It has been studied for its potential applications in medicinal chemistry, including as a building block for the preparation of heterocyclic compounds and as a potential anti-cancer agent. Additionally, 3-methyl-4-nitro-1H-indole exhibits potential antimicrobial and anti-inflammatory properties, making it a versatile compound with a wide range of potential applications in pharmaceuticals and biotechnology.

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Downstream Products

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Relevant articles and documents

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Modulators of ATP-binding cassette transporters

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.