134272-21-2Relevant academic research and scientific papers
Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists
Kusakabe, Ken-Ichi,Tada, Yukio,Iso, Yasuyoshi,Sakagami, Masahiro,Morioka, Yasuhide,Chomei, Nobuo,Shinonome, Satomi,Kawamoto, Keiko,Takenaka, Hideyuki,Yasui, Kiyoshi,Hamana, Hiroshi,Hanasaki, Kohji
, p. 2045 - 2055 (2013/04/24)
Selective CB2 agonists have the potential for treating pain without central CB1-mediated adverse effects. Screening efforts identified 1,2-dihydro-3- isoquinolone 1; however, this compound has the drawbacks of being difficult to synthesize with two asymme
ANTIPRURITICS
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Page/Page column 26; 27, (2008/06/13)
It is intended to provide antipruritics (drugs to control itching, antiitch agents and drugs to stop itching). It is found out that a compound having an agonistic activity to the cannabinoid receptor shows an antipruritics effect.
PYRIDONE DERIVATIVE HAVING AFFINITY FOR CANNABINOID 2-TYPE RECEPTOR
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, (2008/06/13)
It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R' is a group represented by the formula: -Y1-Y2-Y3Ra wherein Y1 is single bond or the like; Y2 is -C(=O)-NH- or the like; Y3 is optionally substituted aryl or the like; R2 is hydrogen or the like; R3 is alkyl or the like; R4 is alkyl or the like; R5 is optionally substituted alkyl or the like; or R3 and R4 taken together with the adjacent atom form cyclic group or the like.
A FACILE SYNTHESIS OF SUBSTITUTED 4-HYDROXY-2-PYRIDONES
Chung, Kun Hoe,Cho, Kwang Yun,Asami, Yasuko,Takahashi, Nobutaka,Yoshida, Shigeo
, p. 99 - 105 (2007/10/02)
Substituted 4-hydroxy-2-pyridones (1a-1d) were easily synthesized from ethyl acetoacetate in good yields via C-alkylation, enamine formation, N-acylation, intramolecular cyclization, and debenzylation.
