51671-51-3Relevant academic research and scientific papers
Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists
Kusakabe, Ken-Ichi,Tada, Yukio,Iso, Yasuyoshi,Sakagami, Masahiro,Morioka, Yasuhide,Chomei, Nobuo,Shinonome, Satomi,Kawamoto, Keiko,Takenaka, Hideyuki,Yasui, Kiyoshi,Hamana, Hiroshi,Hanasaki, Kohji
, p. 2045 - 2055 (2013)
Selective CB2 agonists have the potential for treating pain without central CB1-mediated adverse effects. Screening efforts identified 1,2-dihydro-3- isoquinolone 1; however, this compound has the drawbacks of being difficult to synthesize with two asymme
Visible Light Promoted β-C—H Alkylation of β-Ketocarbonyls via a β-Enaminyl Radical Intermediate
Wang, Dehong,Zhang, Long,Luo, Sanzhong
, p. 311 - 320 (2018/02/21)
A 5πe carbonyl activation mode is reported on the basis of photo-induced single-electron-transfer (SET) oxidation of a secondary enamine. The resultant β-enaminyl radical intermediate was trapped by a wide range of Michael acceptors, producing β-alkylation products of β-ketocarbonyls in a highly efficient manner.
