134274-83-2Relevant academic research and scientific papers
PH-Mediated Selective Synthesis of N-Allylic Alkylation or N-Alkylation Amines with Allylic Alcohols via an Iridium Catalyst in Water
Luo, Nianhua,Zhong, Yuhong,Shui, Hongling,Luo, Renshi
, p. 15509 - 15521 (2021/11/01)
Amination of allylic alcohols is an effective approach in the facile synthesis of N-allylic alkylation or N-alkylation amines. Recently, a series of catalysts were devised to push forward this transformation. However, current synthetic methods are typical
Allyl coupling reaction method and application thereof
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Paragraph 0299-0303, (2021/08/25)
The invention discloses a novel allyl coupling reaction method which takes an allyl thianthene salt as an allylation reagent and respectively takes a carboxylic acid compound. An allylated coupling product is obtained by reacting a substrate with a base in the presence of a base, or directly with a carboxylate compound, an aromatic hydrocarbon/heterocyclic hydrocarbon as a substrate, and at room temperature. The preparation method is mild in condition and free of transition metal participation, can efficiently realize preparation of various allyl ester, allyl substituted amine and allyl substituted aromatic hydrocarbon/heterocyclic hydrocarbon compound, and has an ideal application prospect in the fields of fine chemical engineering, material science and pharmacy.
N-Methylcaprolactam as a Dipolar Aprotic Solvent for Iron-Catalyzed Cross-Coupling Reactions: Matching Efficiency with Safer Reaction Media
Bisz, Elwira,Podchorodecka, Pamela,Szostak, Michal
, p. 1196 - 1199 (2019/01/25)
Although iron-catalysis provides a powerful alternative to the more conventional palladium and nickel in the cross-coupling arena, the major limitation is the necessity for carcinogenic N-methylpyrrolidone as a co-solvent in the vast majority of catalytic reactions. Herein, we introduce N-methylcaprolactam as an efficient, non-toxic and practical dipolar aprotic solvent for iron-catalyzed C(sp2)?C(sp3) alkylative cross-coupling of aryl chlorides and tosylates. The utility of this method is reflected by its wide substrate scope, high yields and capacity to cross-couple challenging alkyl organometallics prone to b-hydride elimination and homocoupling. Considering the broad utility of iron-catalyzed cross-coupling, we envision that N-methylcaprolactam will find wide application as a substitute for carcinogenic NMP.
