13428-19-8

Upstream product

• 95-57-8 2-monochlorophenol 

Downstream Products

• 71260-20-3 Hexadecanoic acid 2-[(2-chloro-phenoxy)-(2-dimethylamino-ethoxy)-phosphoryloxy]-1-hexadecanoyloxymethyl-ethyl ester 
• 138868-79-8 sodium salt of 9-[(1R,2R,3S)-2-hydroxymethyl-3-(hydroxy-(2-chlorophenoxy)phosphoryl)oxymethyl-1-cyclobutyl]guanine 
• 134218-87-4 C₁₅H₁₅ClN₂O₁₂P₂^(2-)*2Na⁽¹⁺⁾ 

Relevant academic research and scientific papers

Hydrogen phosphates: Self initiated organocatalysts for the controlled ring-opening polymerization of cyclic esters

A series of arylhydrogenphosphates and aryldihydrogenphosphates was synthesized and characterized using spectroscopic methods and single crystal X-ray diffraction. These compounds were assessed as catalysts towards the ring-opening polymerization and proved to be potent organocatalysts for the ring-opening polymerization of cyclic esters. The bulk polymerizations were performed in the absence of external initiator. The polymerization proceeds in a controlled fashion which leads to well defined polyesters with narrow molecular weight distributions. In the post polymerization experiments, kinetics, mechanism and monomer concentration effects were investigated. The kinetic results have confirmed the pseudo-living character of the polymerizations and mechanistic studies suggest that the polymerization operates through a cationic mechanism.

Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein

Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Src SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised.

Synthesis of potential UDP-glucuronosyltransferase inhibitors containing a diphosphate function

The synthesis of potential inhibitors of UDP-glucuronosyltransferase, in which the β-phosphate moiety of uridine 5'-diphosphate is linked to phenolic or alcoholic hydroxyl groups, is described.Key intermediates in the formation of the diphosphate function are S-(4-methylphenyl) 2-cyanoethyl phosphorothioate triesters which, after conversion into the corresponding S-(4-methylphenyl) phosphorothioate diesters, react with phosphate monoesters, in the presence of iodine, to give the target molecules.