1342801-42-6Relevant articles and documents
Chemiluminescence determination of human serum albumin based on Co2+-catalyzed 2-(4-tert-butylphenyl)-4,5-di(2-furyl) imidazole/H2O2 system
Kang, Jing,Shen, Jimin,Chen, Zhonglin,Nan, Jun,Huang, Xiao,Han, Lu,Hao, Weiping
, p. 89569 - 89576 (2015)
In this paper, the chemiluminescence (CL) reaction of 2-(4-tert-butylphenyl)-4,5-di(2-furyl) imidazole (t-BDFI) and H2O2 was investigated in alkaline medium. The H2O2 could directly oxidize t-BDFI to produce CL emission. The effects of some metal ions on CL of the t-BDFI/H2O2 system were examined. The results indicated that the addition of Co2+ into the t-BDFI/H2O2 CL system could induce significant enhancement of the CL signal. A CL system of t-BDFI/H2O2/Co2+ was developed. The experiment on the effect of human serum albumin (HSA) on the t-BDFI/H2O2/Co2+ CL system was carried out, and the result indicated that HSA could effectively inhibit the CL signal of this reaction. The inhibited CL intensity is linearly related to the logarithm of concentration of HSA. The linear range of the calibration curve is 5.0 × 10-8 to 1.0 × 10-6 mol L-1, and the corresponding detection limit (3σ) is 2.1 × 10-8 mol L-1. Based on this study, a novel CL method has been developed for the determination of HSA with high sensitivity and good selectivity. The proposed method has been successfully applied to the determination of HSA in human serum samples. This may intrigue researchers into gaining a new interest in investigating the CL property of heterocyclic imidazole derivatives.
Determination Co2+ in vitamin B12 based on enhancement of 2-(4-substituted-phenyl)-4,5-di(2-furyl) imidazole and H 2O2 chemiluminescence reaction
Han, Lu,Zhang, Yumin,Kang, Jing,Tang, Jieli,Zhang, Yihua
, p. 146 - 152 (2011/11/12)
In this paper, three kinds of imidazole derivatives, 2-(4-methylphenyl)-4, 5-di(2-furyl) imidazole (MDFI), 2-(4-nitrophenyl)-4,5-di(2-furyl) imidazole (NDFI), and 2-(4-tert-butylphenyl)-4,5-di(2-furyl) imidazole (t-BDFI) were synthesized. In an alkaline medium, the chemiluminescence (CL) reaction of imidazole derivatives with H2O2 has been investigated. It was also found that MDFI/H2O2 and t-BDFI/H 2O2 systems gave strong CL. When Co2+ was added into the two CL systems, the CL intensity was remarkably enhanced. In the optimum conditions, the CL intensity is linearly related to the logarithm of concentration of Co2+. The linear ranges are 5 × 10 -9-2.5 × 10-7 mol/L for MDFI/H2O 2 system and 5 × 10-9-2.5 × 10-7 mol/L for t-BDFI/H2O2 system, and the corresponding detection limits are 1.2 × 10-9 mol/L and 1.1 × 10 -9 mol/L, respectively. The method was applied to the determination of Co2+ in vitamin B12 injection. Furthermore, the CL mechanism was also discussed.
