1342906-74-4

Upstream product

• 754230-78-9 3-(benzyloxy)-5-bromopyridine-2-amine 
• 24016-03-3 2-amino-3-benzyloxypyridine 
• 188057-49-0 5-bromo-2-iodo-3-hydroxypyridine 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 74115-13-2 5-bromopyridine-3-ol 

Downstream Products

• 1342906-76-6 methyl 3-benzyloxy-5-bromopicolinate 
• 1342906-78-8 methyl 3-benzyloxy-5-phenylpicolinate 
• 1342906-79-9 methyl 3-benzyloxy-5-(3-chlorophenyl)picolinate 
• 1342906-81-3 methyl 5-benzylamino-3-(benzyloxy)picolinate 
• 1342906-82-4 methyl 3-benzyloxy-5-(piperidin-1-yl)picolinate 
• 1342906-83-5 methyl 3-(benzyloxy)-5-(3-hydroxyprop-1-ynyl)picolinate 

Relevant academic research and scientific papers

DIHYDROBENZOFURAN AND INDEN ANALOGS AS CARDIAC SARCOMERE INHIBITORS

Provided are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R1, R2, R3, G1, G2, and G3 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt, thereof for use in methods of treatment heart diseases through cardiac sarcomere inhibtion.

PYRIDINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS

The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS

The invention relates to compounds inhibiting phosphoinositide 3-kinases (PI3K), to pharmaceutical compositions comprising them and therapeutic use thereofin the treatment of disorders associated with PI3K enzymes.

ISOCHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS

Compounds of formula (I) described herein are useful for inhibiting phosphoinositide 3-kinases (PI3K) and the treatment of disorders associated with PI3K enzymes.

Straightforward and efficient synthesis of 3-benzyloxy-4-bromopicolinate ester and 3-benzyloxy-5-bromopicolinate ester, common building blocks for pharmaceuticals and agrochemicals

A practical and rapid preparation of 3-benzyloxy-4-bromo and 3-benzyloxy-5-bromopicolinate esters 10 and 16 was developed in four steps, respectively, in 38% and 31% overall yield. Then their viability as partners for cross-coupling reactions has been evaluated in Suzuki-Miyaura, Hartwig-Buchwald, and Sonogashira reactions to synthesize biologically relevant targets. The preparation of these two highly functionalizable pyridines 10 and 16 has been never described to date in the literature and could be used as common building block for the preparation of several biologically active compounds or agrochemical products.